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Fig. 3 | BMC Ecology and Evolution

Fig. 3

From: Synergistic inter-clonal cooperation involving crosstalk, co-option and co-dependency can enhance the invasiveness of genetically distant cancer clones

Fig. 3

TGF-β1 is responsible for the MDA-induced enhanced migration of MCF7. a The effect of a TGF-β receptor I inhibitor (TGFβRI; 10 µM) on the migration of MCF7 control (CT) cultures as well as cultures exposed to either TGF-β1 (as a positive control), MCF7_CM or MDA_CM. b The effect of MDA_CM neutralized with antibodies (1D11) against TGF-β 1, 2, and 3 (CM + 1D11; 2 µg/ml) on the migration of MCF7 (wound-healing assay; 72 h). c The effect of a TGF-β receptor I inhibitor on the migration of MDA (wound-healing assay; 24 h). Error bars indicate SEM (n = 3). + refers to control (CT), and * refers to treatments. ns = not significant; ++/** denote p < 0.01; **** denotes p < 0.0001

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BMC Ecology and Evolution

ISSN: 2730-7182

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