Fig. 7
From: Dosage balance acts as a time-dependent selective barrier to subfunctionalization
Concentration of hydrophobic surface area for different ratios of interacting partners. Concentration of hydrophobic surface area is shown on a log scale, as well as equilibrium constant values (Keq). When the Keq values are larger, and the ratio of interacting partners ([A]total/[B]total) is closer to one, the sum of [A]free and [B]free is smaller. Similarly, when the Keq values are smaller, and the ratio of interacting partners ([A]total/[B]total) is further from one, the sum of [A]free and [B]free is larger. This is possibly explained by the fact that overall exposed hydrophobic patches would be lower if A and B are in balance and are tight binders