Table 1 Summary of BMR-dependent traits that may influence the carcinogenesis process in mice characterized by a high basal metabolic rate
BMR correlated trait | Trait response | Statistical reliability | References |
|---|---|---|---|
Mass of metabolically active organs | Increase | P < 0.0001; (n = 40) | [63] |
Hepatocyte size | Increase | P = 0.002; (n = 15) | [19] |
Skin epithelium cell size | Decrease | P = 0.007; (n = 15) | [19] |
Immune response (KLH) | Decrease | P < 0.01; (n = 26) | [54] |
Oxidative damage | Increase | P < 0.01; (n = 20) | [55] |
Heavy metal intoxicate | Increase | P < 0.001; (n = 7) | [53] |
Hepatocyte mTOR expression | Increase | P < 0.001; (n = 20) | [43] |
Colorectal cancer development | Increase | P < 0.001; (n = 12) | (Unpublished data) |