Fig. 1
From: Diverse functions associate with non-coding polymorphisms shared between humans and chimpanzees
Schematic of the criteria for identifying the SP sets used in this study. A previous study [4] reported a set of 125 candidate regions with two or more non-coding human-chimp shared polymorphisms (SP) within 4 kb. We refined this set based on several additional lines of evidence. First, we considered scores from two balancing selection statistics (NCD and BetaScan2) to create a set of 60 haplotypes with 133 candidate balanced SPs (cbSP). We consider regions with evidence for balancing selection in at least one population from NCD, or regions containing variants with BetaScan2 scores equal or higher than 2.0. We further filtered this set to the 19 haplotypes additionally predicted to be at least 140,000 generations old by ARGweaver or contain at least 3 SPs within 4 kb. These haplotypes include 51 candidate trans-species SP (ctSP) with the highest likelihood of LTBSs