Fig. 1

Landscapes of GC% and GARP% in Eutheria and Metatheria. For each of the 15,727 genes included in this comparative analysis we calculated GC content (GC%) and relative occurrence of glycine, alanine, arginine and proline in predicted proteins (GARP%). Gene data were integrated with the values of surrounding genes (50 genes on each side). Alternating grey and white zones demarcate individual chromosomes. In a–c, genes were ordered according to a Eutherian (Homo sapiens) genome, while in d–f the gene order was Metatherian (Monodelphis domestica). a-b) GC% (black) and GARP% (green) landscape distribution for a Eutherian (Felis catus; cat, a) and a Metatherian (Phascolarctos cinereus; koala, b). c A heatmap of the GC% landscape for all 12 Eutheria and 4 Metatherian in the following order: 1 Sus scrofa, 2 Equus asinus, 3 Orcinus orca, 4 Felis catus domestica, 5 Cricetulus griseus, 6 Rattus norvegicus, 7 Oryctolagus cuniculus, 8 Callithrix jacchus, 9 Trichechus manatus latirostris, 10 Loxodonta africana, 11 Chrysochloris asiatica, 12 Orycteropus afer afer, 13 Vombatus ursinus, 14 Sarcophilus harrisii, 15 Phascolarctos cinereus, 16 Monodelphis domestica. In the gene ranking of both genomes a distinct Eutherian and Metatherian GC% landscape can be discerned