Evolution of transcriptional control of antigenic variation and virulence in human and ape malaria parasites

Table 1 Orthologous genes encoding proteins implicated in var gene regulation

	SET10	Sir2A	Sir2B	WRN	RQ1	SET2	JmJC1	PTEF
P. alderi	PADL01_1221600	PADL01_1327800	PADL01_1451400	PADL01_1429900	PADL01_0917600	PADL01_1321000	PADL01_0809000	PADL01_0201200
P. gaboni	PGABG01_1219800	PGABG01_1327000	PGABG01_1450200	PGABG01_1428600	PGABG01_0916000	PGABG01_1320200	PGABG01_0809800	PGABG01_0200100
P. blacklocki	PBLACG01_1220400	PBLACG01_1327100	PBLACG01_1450800	PBLACG01_1429300	PBLACG01_0918200	PBLACG01_1320300	PBLACG01_0809600	*
P. billcollinsi	PBILCG01_1221100	PBILCG01_1329300	PBILCG01_1450900	PBILCG01_1430500	PBILCG01_0922000	PBILCG01_1322500	PBILCG01_0815300	PBILCG01_0205100
P. reichenowi	PRG01_1224300	PRG01_1331000	PRG01_1451400	PRG01_1429900	PRG01_0926000	PRG01_1324200	PRG01_0812700	PRG01_0201700
P. praefalciparum	PPRFG01_1233800	PPRFG01_1330800	PPRFG01_1452100	PPRFG01_1430600	PPRFG01_0917400	PPRFG01_1324000	PPRFG01_0811300	PPRFG01_0202500
P. falciparum	PF3D7_1221000	PF3D7_1328800	PF3D7_1451400	PF3D7_1429900	PF3D7_0918600	PF3D7_1322100	PF3D7_0809900	PF3D7_0202400
P. vivax	PVX_123685	PVX_082385	PVX_117910	PVX_085045	PVX_099345	PVX_116765	PVX_123283	missing
P. berghei	PBANKA_1436200	PBANKA_1343800	PBANKA_1315100	PBANKA_1014800	PBANKA_0819500	missing	missing	missing
P. gallinaceum	PGAL8A_00535100	PGAL8A_00241100	PGAL8A_00210600	PGAL8A_00301500	PGAL8A_00431400	PGAL8A_00234100	PGAL8A_00526200	missing

The species names are listed on the left and the gene annotation number for each protein are listed in columns under each protein name. Genes encoded SET2 and JmJC1 are not found at the syntenic genomic positions in P. berghei, and syntenic genes encoding PTEF are not found in either P. vivax, P. berghei or P. gallinaceum (denoted with italicized text). *The existence of PTEF in P. blacklocki could not be determined because the syntenic region of the genome is incomplete in the most recent genome sequence assembly for this species

ISSN: 2730-7182