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Table 1 Results of selection tests according to six different methods (only sites with suggestion of selection by two or more methods are shown); x—positive selection as indicated by a significant selection test signal

From: Positive selection on two mitochondrial coding genes and adaptation signals in hares (genus Lepus) from China

  Site Ancestral Aminoacid change PAML DATAMONKEY TreeSAAP (Proprety) Provean Domain DYNAMUT
SLAC FEL MEME FUBAR ΔΔG (kcal/mol) action
ND4 29 V A x x (pK’) − 0.001 Trans − 0.127 Destabilizing
101 S A   x x () 0.547 Trans 1.098 Stabilizing
185 H S x x x x 0.498 Inter 0.461 Stabilizing
187 L P x x    x () − 0.085 Inter − 0.076 Destabilizing
246 I V x x (pK’) − 0.627 Trans − 0.643 Destabilizing
305 T S   x x x − 3.444 Trans 0.052 Stabilizing
425 N V   x x − 3.685 Matrix 0.01 Stabilizing
CytB 23 T A x x x () 1.406 Matrix 0.518 Stabilizing
194 M L x x (pK’) 0.045 Trans 0.274 Stabilizing
356 I V x x (pK’) 0.002 Trans − 0.083 Destabilizing
  1. Replacements inferred to be function-altering by PROVEAN and DYNAMUT are indicated in bold
  2. Equil. Const. – ioniza., COOH (pK’); α − helical tendencies (Pα)