| Site | Ancestral | Aminoacid change | PAML | DATAMONKEY | TreeSAAP (Proprety) | Provean | Domain | DYNAMUT | ||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SLAC | FEL | MEME | FUBAR | ΔΔG (kcal/mol) | action | ||||||||
ND4 | 29 | V | A | x | – | – | – | – | x (pK’) | − 0.001 | Trans | − 0.127 | Destabilizing |
101 | S | A | – | – |  | x | – | x (Pα) | − 0.547 | Trans | 1.098 | Stabilizing | |
185 | H | S | – | x | x | x | x | – | 0.498 | Inter | 0.461 | Stabilizing | |
187 | L | P | – | x | x |  |  | x (Pα) | − 0.085 | Inter | − 0.076 | Destabilizing | |
246 | I | V | – | – | x | – | – | x (pK’) | − 0.627 | Trans | − 0.643 | Destabilizing | |
305 | T | S | – |  | x | x | x | – | − 3.444 | Trans | 0.052 | Stabilizing | |
425 | N | V | – |  | x | x | – | – | − 3.685 | Matrix | 0.01 | Stabilizing | |
CytB | 23 | T | A | – | x | x | – | – | x (Pα) | − 1.406 | Matrix | 0.518 | Stabilizing |
194 | M | L | – | – | – | x | – | x (pK’) | − 0.045 | Trans | 0.274 | Stabilizing | |
356 | I | V | – | – | x | – | – | x (pK’) | 0.002 | Trans | − 0.083 | Destabilizing |