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Table 6 Gene expression changes in evolved yeast strains vs. fitness landscape

From: Genetic interaction network has a very limited impact on the evolutionary trajectories in continuous culture-grown populations of yeast

Impact in the interaction network Downregulated Upregulated
Evolution of cog7Δ  
On cog7Δ** Deleterious 12 45
Beneficial 6 2
Evolution of nup133Δ
On nup133Δ Deleterious 7 11
Beneficial 3 3
Evolution of msh2Δ
On msh2Δ** Deleterious 14 68
Beneficial 24 10
Evolution of msh2Δ cog7Δ
On cog7Δ** Deleterious 15 62
Beneficial 9 4
On msh2Δ** Deleterious 14 68
Beneficial 21 10
Evolution of msh2Δ nup133Δ
On nup133Δ Deleterious 4 9
Beneficial 6 4
On msh2Δ Deleterious 13 19
Beneficial 14 9
  1. **Statistically significant (p-value < 0.01) under-representation of deleterious genes that were down-regulated (according to the Fisher exact test)