Genetic interaction network has a very limited impact on the evolutionary trajectories in continuous culture-grown populations of yeast

Table 6 Gene expression changes in evolved yeast strains vs. fitness landscape

Impact in the interaction network		Downregulated	Upregulated
Evolution of cog7Δ
On cog7Δ**	Deleterious	12	45
On cog7Δ**	Beneficial	6	2
Evolution of nup133Δ
On nup133Δ	Deleterious	7	11
On nup133Δ	Beneficial	3	3
Evolution of msh2Δ
On msh2Δ**	Deleterious	14	68
On msh2Δ**	Beneficial	24	10
Evolution of msh2Δ cog7Δ
On cog7Δ**	Deleterious	15	62
On cog7Δ**	Beneficial	9	4
On msh2Δ**	Deleterious	14	68
On msh2Δ**	Beneficial	21	10
Evolution of msh2Δ nup133Δ
On nup133Δ	Deleterious	4	9
On nup133Δ	Beneficial	6	4
On msh2Δ	Deleterious	13	19
On msh2Δ	Beneficial	14	9

**Statistically significant (p-value < 0.01) under-representation of deleterious genes that were down-regulated (according to the Fisher exact test)

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