From: Molecular evolutionary analysis of human primary microcephaly genes
Gene | Model | Parameter estimation (ω) | lnL | P value | q value |
---|---|---|---|---|---|
CEP135 | CmC-Primate | p0 = 0.560, ω0 = 0.0231, p1 = 0.142,ω1 = 1.0, p2 = 0.298, ωnp = 0.251, ωp = 0.315 | − 26,080.0893 | 0.057 | 0.34 |
CmC-Simians | p0 = 0.296, ω0 = 0.27, p1 = 0.141, ω1 = 1.0, p2 = 0.56, ωns = 0.023, ωs = 0.021 | − 26,081.8471 | 0.75 | 0.66 | |
CmC-catarrhini | p0 = 0.293, ω0 = 0.271, p1 = 0.141, ω1 = 1.0, p2 = 0.57, ωnc = 0.023, ωc = 0.0397 | − 26,081.3823 | 0.31 | 0.58 | |
CmC-greatapes | p0 = 0.295, ω0 = 0.269, p1 = 0.141, ω1 = 1.0, p2 = 0.564, ωng = 0.0235, ωg = 0.0184 | − 26,081.8801 | 0.85 | 0.66 | |
CmC-hominini | p0 = 0.56, ω0 = 0.023 p1 = 0.141, ω1 = 1.0, p2 = 0.296, ωnh = 0.27, ωh = 0.59 | − 26,081.1383 | 0.22 | 0.57 | |
M2a_rel | p0 = 0.295, ω0 = 0.269, p1 = 0.0141, ω1 = 1.0, p2 = 0.564, ω2 = 0.0235 | − 26,081.8982 | NA | NA | |
ZNF335 | CmC-Primate | p0 = 0.75, ω0 = 0.015, p1 = 0.029, ω1 = 1.0, p2 = 0.221, ωnp = 0.255, ωp = 0.285 | − 32,294.0420 | 0.30 | 0.58 |
CmC-simians | p0 = 0.751, ω0 = 0.0155, p1 = 0.029, ω1 = 1.0, p2 = 0.22, ωns = 0.256, ωs = 0.312 | − 32,293.5981 | 0.16 | 0.57 | |
CmC-catarrhini | p0 = 0.751, ω0 = 0.0154, p1 = 0.029, ω1 = 1.0, p2 = 0.22, ωnc = 0.266, ωc = 0.27 | − 32,293.5586 | 0.15 | 0.57 | |
CmC-greatapes | p0 = 0.75, ω0 = 0.0154, p1 = 0.029, ω1 = 1.0, p2 = 0.22, ωng = 0.259, ωg = 0.297 | − 32,294.4826 | 0.66 | 0.66 | |
CmC-hominini | p0 = 0.75, ω0 = 0.0154, p1 = 0.029, ω1 = 1.0, p2 = 0.22, ωnh = 0.26, ωh = 0.25 | − 32,294.5720 | 0.92 | 0.69 | |
M2a_rel | p0 = 0.75, ω0 = 0.015, p1 = 0.029, ω1 = 1.0, p2 = 0.221, ω2 = 0.26 | − 32,294.5769 | NA | NA | |
PHC1 | CmC-Primate | p0 = 0.784, ω0 = 0.020, p1 = 0.021, ω1 = 1.0, p2 = 0.195, ωnp = 0.339, ωp = 0.395 | − 20,737.4013 | 0.29 | 0.58 |
CmC-simians | p0 = 0.194, ω0 = 0.348, p1 = 0.021, ω1 = 1.0, p2 = 0.78, ωns = 0.020, ωs = 0.018 | − 20,737.9248 | 0.82 | 0.66 | |
CmC-catarrhini | p0 = 0.78, ω0 = 0.020, p1 = 0.021, ω1 = 1.0, p2 = 0.19, ωnc = 0.347, ωc = 0.364 | − 20,737.9367 | 0.86 | 0.66 | |
CmC-greatapes | p0 = 0.78, ω0 = 0.020, p1 = 0.021, ω1 = 1.0, p2 = 0.19, ωng = 0.349, ωg = 0.179 | − 20,737.3879 | 0.29 | 0.58 | |
CmC-hominini | p0 = 0.78, ω0 = 0.020, p1 = 0.021, ω1 = 1.0, p2 = 0.19, ωnh = 0.35, ωh = 0.13 | − 20,737.5787 | 0.38 | 0.65 | |
M2a_rel | p0 = 0.784, ω0 = 0.020, p1 = 0.021, ω1 = 1.0, p2 = 0.194, ω2 = 0.348 | − 20,737.9512 | NA | NA | |
SASS6 | CmC-Primate | p0 = 0.612, ω0 = 0.017, p1 = 0.077, ω1 = 1.0, p2 = 0.310, ωnp = 0.253, ωp = 0.270 | − 14,706.9216 | 0.67 | 0.66 |
CmC-simians | p0 = 0.58, ω0 = 0.013, p1 = 0.082, ω1 = 1.0, p2 = 0.34, ωns = 0.214, ωs = 0.499 | − 14,697.4440 | 0.00001 | 0.0003 | |
CmC-catarrhini | p0 = 0.31, ω0 = 0.26, p1 = 0.077, ω1 = 1.0, p2 = 0.62, ωnc = 0.017, ωc = 0.024 | − 14,706.9516 | 0.72 | 0.66 | |
CmC-greatapes | p0 = 0.61, ω0 = 0.17, p1 = 0.078, ω1 = 1.0, p2 = 0.31, ωng = 0.25, ωg = 0.47 | − 14,706.3050 | 0.23 | 0.57 | |
CmC-hominini | p0 = 0.62, ω0 = 0.017, p1 = 0.077, ω1 = 1.0, p2 = 0.31, ωnh = 0.26, ωh = 1.082 | − 14,705.0071 | 0.045 | 0.33 | |
M2a_rel | p0 = 0.614, ω0 = 0.017, p1 = 0.077, ω1 = 1.0, p2 = 0.308, ω2 = 0.259 | − 14,707.0141 | NA | NA | |
CDK6 | CmC-Primate | p0 = 0.895, ω0 = 0.011, p1 = 0.012, ω1 = 1.0, p2 = 0.0926, ωnp = 0.298, ωp = 0.257 | − 5156.14749 | 0.76 | 0.66 |
CmC-Simians | p0 = 0.897, ω0 = 0.012, p1 = 0.014, ω1 = 1.0, p2 = 0.088, ωns = 0.271, ωs = 0.428 | − 5155.82423 | 0.39 | 0.65 | |
CmC-catarrhini | p0 = 0.902, ω0 = 0.012, p1 = 0.011, ω1 = 1.0, p2 = 0.087, ωnc = 0.32, ωc = 0.16 | − 5156.01860 | 0.55 | 0.66 | |
CmC-greatapes | p0 = 0.089, ω0 = 0.298, p1 = 0.012, ω1 = 1.0, p2 = 0.899, ωng = 0.012, ωg = 0.00 | − 5156.08170 | 0.63 | 0.66 | |
CmC-hominini | p0 = 0.089, ω0 = 0.296, p1 = 0.012, ω1 = 1.0, p2 = 0.898, ωnh = 0.012, ωh = 0.00 | − 5156.12730 | 0.71 | 0.66 | |
M2a_rel | p0 = 0.897, ω0 = 0.011, p1 = 0.012, ω1 = 1.0, p2 = 0.0906, ω2 = 0.294 | − 5156.19494 | NA | NA | |
MFSD2A | CmC-Primate | p0 = 0.731, ω0 = 0.0152, p1 = 0.062, ω1 = 1.0, p2 = 0.207, ωnp = 0.257, ωp = 0.279 | − 11,299.7769 | 0.66 | 0.66 |
CmC-simians | p0 = 0.719, ω0 = 0.014, p1 = 0.066, ω1 = 1.0, p2 = 0.21, ωns = 0.23, ωs = 0.38 | − 11,297.2803 | 0.02 | 0.30 | |
CmC-catarrhini | p0 = 0.725, ω0 = 0.015, p1 = 0.065, ω1 = 1.0, p2 = 0.21, ωnc = 0.25, ωc = 0.33 | − 11,299.5559 | 0.43 | 0.66 | |
CmC-greatapes | p0 = 0.73, ω0 = 0.015, p1 = 0.062, ω1 = 1.0, p2 = 0.21, ωng = 0.262, ωg = 0.289 | − 11,299.8560 | 0.85 | 0.66 | |
CmC-hominini | p0 = 0.73, ω0 = 0.015, p1 = 0.061, ω1 = 1.0, p2 = 0.21, ωnh = 0.266, ωh = 0.196 | − 11,299.8222 | 0.75 | 0.66 | |
M2a_rel | p0 = 0.732, ω0 = 0.0154, p1 = 0.061, ω1 = 1.0, p2 = 0.206, ω2 = 0.265 | -11,299.8738 | NA | NA | |
CIT | CmC-Primate | p0 = 0.89, ω0 = 0.0058, p1 = 0.014, ω1 = 1.0, p2 = 0.095, ωnp = 0.24, ωp = 0.19 | − 35,246.2438 | 0.18 | 0.57 |
CmC-simians | p0 = 0.095, ω0 = 0.226, p1 = 0.015, ω1 = 1.0, p2 = 0.89, ωns = 0.0059, ωs = 0.0043 | − 35,246.9740 | 0.57 | 0.66 | |
CmC-catarrhini | p0 = 0.094, ω0 = 0.227, p1 = 0.015, ω1 = 1.0, p2 = 0.89, ωnc = 0.0057, ωc = 0.0088 | − 35,246.8939 | 0.49 | 0.66 | |
CmC-greatapes | p0 = 0.89, ω0 = 0.0058, p1 = 0.015, ω1 = 1.0, p2 = 0.094, ωng = 0.2279, ωg = 0.2074 | − 35,247.1167 | 0.86 | 0.66 | |
CmC-hominini | p0 = 0.89, ω0 = 0.0057, p1 = 0.015, ω1 = 1.0, p2 = 0.095, ωnh = 0.224, ωh = 0.379 | − 35,246.9556 | 0.55 | 0.66 | |
M2a_rel | p0 = 0.89, ω0 = 0.0058, p1 = 0.015, ω1 = 1.0, p2 = 0.095, ω2 = 0.227 | − 35,247.1321 | NA | NA | |
KIF14 | CmC-Primate | p0 = 0.43, ω0 = 0.043, p1 = 0.15, ω1 = 1.0, p2 = 0.42, ωnp = 0.36, ωp = 0.39 | − 31,056.0434 | 0.58 | 0.66 |
CmC-simians | p0 = 0.43, ω0 = 0.043, p1 = 0.14, ω1 = 1.0, p2 = 0.42, ωns = 0.36, ωs = 0.42 | − 31,055.4805 | 0.23 | 0.57 | |
CmC-catarrhini | p0 = 0.43, ω0 = 0.042, p1 = 0.15, ω1 = 1.0, p2 = 0.42, ωnc = 0.36, ωc = 0.41 | − 31,055.9687 | 0.50 | 0.66 | |
CmC-greatapes | p0 = 0.42, ω0 = 0.37, p1 = 0.15, ω1 = 1.0, p2 = 0.43, ωng = 0.042, ωg = 0.13 | − 31,054.6979 | 0.083 | 0.42 | |
CmC-hominini | p0 = 0.42, ω0 = 0.37, p1 = 0.15, ω1 = 1.0, p2 = 0.43, ωnh = 0.042, ωh = 0.25 | − 31,053.9072 | 0.03 | 0.30 | |
M2a_rel | p0 = 0.42, ω0 = 0.37, p1 = 0.15, ω1 = 1.0, p2 = 0.43, ω2 = 0.043 | − 31,056.1959 | NA | NA |