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Table 2 Positive selected sites detected by using M8 codon substitution site model

From: Molecular evolutionary analysis of human primary microcephaly genes

Gene

Data sets

No. of codon under positive selection

Sites under positive selection (BEB > 80%)

ZNF335

Non-primate mammals

7

225Aα, 365P, 414G, 761S, 830P, 983Vα, 1133S

Mammals

7

93H, 225Aα, 738A, 761S, 830P, 938Vβ, 1133S

SASS6

Non-primate mammals

7

99A, 241I, 494 T, 524S, 550 T, 581Iα, 585C

CIT

Non-primate mammals

8

11P, 12Lα, 17A, 150R, 279Tβ, 334F, 1479 T, 1723I

KIF14

Primates

12

107L, 203P, 204S, 342 V, 875Hβ, 1413F, 1474S, 1499Rα, 1532Q, 1602 K, 1605H, 1612G

Mammals

10

29A, 107L, 166I, 203P, 204S, 232 T, 1303I, 1525H, 1608Sα, 1632S

  1. Positively selected sites are identifies using Bayes Empirical Bayes (BEB) analysis implemented in M8 codon substitution site model with cutoff of posterior probability > 0.80%. Sites with P value <  = 0.05 are labeled as α and with P value <  = 0.01 are labeled as β