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Table 1 Signature of pervasive positive selection in primary microcephaly genes

From: Molecular evolutionary analysis of human primary microcephaly genes

Genes

Data sets

No. of sequences

(M2-M1)

(M8-M7)

(M8-M8a)

   

LRT

P value

q Value

LRT

P value

q Value

LRT

P value

q Value

ZNF335

Nonprimate mammals

27

0

1

1

24.13

0.000005

0.000013

9.34

0.002

0.008

 

Mammals

45

0

1

1

27.41

0.000001

0.000005

18.62

0.00002

0.0002

SASS6

Nonprimate mammals

25

0

1

1

21.58

0.00002

0.00004

7.196

0.007

0.02

CIT

Nonprimate mammals

22

0

1

1

38.84

 < 0.0000001

 < 0.0000001

18.21

0.00002

0.0002

 

Mammals

37

0.000002

1

1

24.4

0.000005

0.00001

0.002

0.96

0.80

KIF14

Primates

17

13.46

0.002

0.00

20.76

0.00003

0.0006

11.63

0.0006

0.004

 

Mammals

29

0

1

1

26.67

0.0000001

0.000005

10.36

0.001

0.005

  1. Positive selection is inferred if two out of three site model comparisons significantly reject null hypothesis using the cutoff of q value 0.05. Null models: M1, M7, and M8a, Alternative models: M2 and M8, LRT: likelihood ratio test. False discovery rate q value corrections over p values were calculated using q value package in R