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Table 1 Enrichments in CNS region-specific genes for the tested and reference gene groups

From: Region-specific expression of young small-scale duplications in the human central nervous system

Reference groupa Tested group for CNS region-specificitya Percentage of CNS region-specific genes in the tested group (%) Chi-squared test P-valueb Odds ratioc
Protein coding genes Paralogous genes 19.2 2.045E−18* 1.48
Paralogous genesd WGD genes 15.7 1.061E−18* 0.64
SSD genes 22.6 9.022E−11* 1.39
ySSD genes 28.6 6.341E−18* 1.82
SSD genes ySSD genes 28.6 3.483E−09* 1.62
oSSD genes 15.6 2.729E−13* 0.52
WGD + wSSD genes wSSD genes 24.0 5.185E−12* 1.69
  1. aAbbreviations for gene duplication categories: WGD (Whole-Genome Duplication), SSD (Small-Scale Duplication), ySSD (younger SSD occuring after WGD events), oSSD (older SSD occuring before WGD events) and wSSD (WGD-old SSD occuring around WGD events)
  2. bApplication of Chi-squared tests (or of Fisher’s exact test when the Chi-squared test could not be applied) with a corrected p-value threshold = 7.14E-03 (Bonferroni correction for 7 statistical tests)
  3. cThe odds ratio (> 1 or < 1) indicates the group (tested or non-tested respectively) in which there is an enrichment
  4. dThe paralog reference group includes the genes belonging to WGD, SSD and WGD-SSD categories and the paralogs without annotation