Fig. 5

In silico cichlid jaw regulatory networks: highlights of important interactions between in silico annotated gene regulatory networks derived from OJA vs LPJA differentially expressed genes. The in silico annotations and interactions are deduced based on available data for vertebrates in FunCoup 3.0 [51], STRING v10 [52], and a meticulous literature search. The solid lines with arrow and blocked ends indicate potential inductive or repressive regulatory interactions with evidential bases from studies of vertebrates. The dashed lines indicate potential regulatory interaction found in this study but without functional support. The predicted TF(s) upstream of each each sub-module are depicted in square shape gene symbol with their related functions marked. The red, blue and white shadings for genes respectively indicate increased expression in oral and pharyngeal jaws, and no expression difference between the jaws