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Table 2 Genes identified as evolving under positive selection

From: Positive natural selection in primate genes of the type I interferon response

Induction genes evolving under positive selection

Interferon-stimulated genes evolving under positive selection

CASP10

ADAR*

CIITA*

APOBEC3F

CISH

APOBEC3G*

DDX58*

APOL2*

DDX60*

APOL6*

EPOR

BST2*

IFI16*

CCL8

IFNAR1*

CD47

IFNAR2

CEACAM1

MAVS*

CRP

MB21D1*

DAPK1

MNDA

EIF2AK2*†

OAS1*

GBP2*

OAS2*

IFI27

PTPRC

IFI44

PYHIN1

IFI44L

RNASEL*

IFI6

SPP1

IFIT1*

STAT2*

IFIT2*

TLR1*

MLKL

TLR2*

MX1*

TLR4*

MX2*

TLR5*

PHF11

TLR6*

RSAD2*

TLR8*

RTP4*

TMEM173*

SAMD9

TRIM21*

SAMHD1*

TRIM25*

SLFN12*

TYK2

TAGAP

 

TMEM140

 

TNK2

 

TRIM22*

 

TRIM5*

 

ZC3HAV1*

  1. Genes that have been previously identified as rapidly evolving in primates (*) and which genes have known interactions with pathogenic elements () are from the following studies: [27, 42, 49,50,51,52,53,54,55,56,57,58,59,60,61,62,63,64]
  2. * Previously identified as being under positive selection in primates
  3. † Published interaction with pathogen