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Table 1 CHIKV amino acid mutations associated with phenotype change in vector

From: The origins of dengue and chikungunya viruses in Ecuador following increased migration from Venezuela and Colombia

Protein Amino acid substitution Phenotype Asian lineage Asian lineage Ecuador cluster only
E1 A226V Enhanced infection of Ae .albopictus [27] A A
E1 A98T Restricts positive selection of the Ae. albopictus-adaptive E1-A226V substitution [28, 29] T T
E1 K211E Enhanced fitness in Ae aegypti in background of E1-226A [30] E E
E2 V264A V V
E2 K233E/Q Enhanced infection of Ae. albopictus [28] K K
E2 K234E Enhanced infection of Ae. albopictus [28] K K
E2 K252Q Enhanced infection of Ae. albopictus – secondary mutation [28] K K
E2 R198Q Enhanced infection of Ae. albopictus, synergistic with E3-18F in background of E1-226V [28] R R
E2 L210Q Enhanced infection of Ae. albopictus, synergistic with E3:18F in background of E1:226V [28, 31] L L
E3 S18F Enhanced infection of Ae. albopictus, synergistic with E2:R198Q [28] S, F S
  1. Bold and underline - vector adaptive residues