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Table 1 CHIKV amino acid mutations associated with phenotype change in vector

From: The origins of dengue and chikungunya viruses in Ecuador following increased migration from Venezuela and Colombia

ProteinAmino acid substitutionPhenotypeAsian lineageAsian lineage Ecuador cluster only
E1A226VEnhanced infection of Ae .albopictus [27]AA
E1A98TRestricts positive selection of the Ae. albopictus-adaptive E1-A226V substitution [28, 29]TT
E1K211EEnhanced fitness in Ae aegypti in background of E1-226A [30]EE
E2V264AVV
E2K233E/QEnhanced infection of Ae. albopictus [28]KK
E2K234EEnhanced infection of Ae. albopictus [28]KK
E2K252QEnhanced infection of Ae. albopictus – secondary mutation [28]KK
E2R198QEnhanced infection of Ae. albopictus, synergistic with E3-18F in background of E1-226V [28]RR
E2L210QEnhanced infection of Ae. albopictus, synergistic with E3:18F in background of E1:226V [28, 31]LL
E3S18FEnhanced infection of Ae. albopictus, synergistic with E2:R198Q [28]S, FS
  1. Bold and underline - vector adaptive residues