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Table 1 CHIKV amino acid mutations associated with phenotype change in vector

From: The origins of dengue and chikungunya viruses in Ecuador following increased migration from Venezuela and Colombia

Protein

Amino acid substitution

Phenotype

Asian lineage

Asian lineage Ecuador cluster only

E1

A226V

Enhanced infection of Ae .albopictus [27]

A

A

E1

A98T

Restricts positive selection of the Ae. albopictus-adaptive E1-A226V substitution [28, 29]

T

T

E1

K211E

Enhanced fitness in Ae aegypti in background of E1-226A [30]

E

E

E2

V264A

V

V

E2

K233E/Q

Enhanced infection of Ae. albopictus [28]

K

K

E2

K234E

Enhanced infection of Ae. albopictus [28]

K

K

E2

K252Q

Enhanced infection of Ae. albopictus – secondary mutation [28]

K

K

E2

R198Q

Enhanced infection of Ae. albopictus, synergistic with E3-18F in background of E1-226V [28]

R

R

E2

L210Q

Enhanced infection of Ae. albopictus, synergistic with E3:18F in background of E1:226V [28, 31]

L

L

E3

S18F

Enhanced infection of Ae. albopictus, synergistic with E2:R198Q [28]

S, F

S

  1. Bold and underline - vector adaptive residues