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Table 8 Sitewise substitution rates in TAED lineages sorted by selective pressure and structural features

From: Characterizing lineage-specific evolution and the processes driving genomic diversification in chordates

  Positively Selected Lineages (dN/dS > 1) Negatively Selected Lineages (dN/dS < 0.5)
Substituted Sites p All Sites Substituted Sites p All Sites
Helix 30.2826% < 0.0001 34.0597% 35.2377% < 0.0001 36.6327%
Exposed 17.1142% 0.0002 16.4580% 20.2511% < 0.0001 17.3397%
Buried 13.1684% < 0.0001 17.6017% 14.9866% < 0.0001 19.2929%
α-Helix 26.1346% < 0.0001 30.1108% 31.1229% < 0.0001 32.7617%
Exposed 14.3764% 0.1659 14.1740% 17.5250% < 0.0001 15.1730%
Buried 11.7582% < 0.0001 15.9368% 13.5979% < 0.0001 17.5887%
310 Helix 3.4956% 0.0098 3.3039% 3.5115% < 0.0001 3.2213%
Exposed 2.3597% < 0.0001 2.0045% 2.4163% < 0.0001 1.8907%
Buried 1.1359% 0.0004 1.2994% 1.0952% < 0.0001 1.3306%
π-Helix 0.6524% 0.8047 0.6449% 0.6033% < 0.0001 0.6497%
Exposed 0.3780% < 0.0001 0.2794% 0.3098% < 0.0001 0.2761%
Buried 0.2743% 0.0005 0.3655% 0.2935% < 0.0001 0.3736%
β-Sheet 23.2104% < 0.0001 21.7820% 18.2981% < 0.0001 19.8385%
Exposed 8.9360% < 0.0001 7.1998% 7.3255% < 0.0001 6.2661%
Buried 14.2744% 0.0361 14.5822% 10.9726% < 0.0001 13.5724%
β-Bridge 1.1095% 0.7913 1.0984% 0.9888% < 0.0001 1.0382%
Exposed 0.5644% 0.0004 0.4641% 0.4876% < 0.0001 0.4194%
Buried 0.5451% 0.0081 0.6343% 0.5012% < 0.0001 0.6188%
Turn 12.0729% < 0.0001 11.0540% 12.3561% < 0.0001 11.0859%
Exposed 9.7554% < 0.0001 8.3283% 9.9588% < 0.0001 8.1517%
Buried 2.3175% < 0.0001 2.7257% 2.3973% < 0.0001 2.9342%
Bend 10.4763% < 0.0001 9.7416% 10.2628% < 0.0001 9.6989%
Exposed 7.9179% < 0.0001 6.8552% 7.8004% < 0.0001 6.6547%
Buried 2.5584% < 0.0001 2.8864% 2.4624% < 0.0001 3.0443%
Coil 22.8482% 0.0006 22.2643% 22.8565% < 0.0001 21.7058%
Exposed 15.2151% < 0.0001 13.2976% 15.3522% < 0.0001 12.7858%
Buried 7.6331% < 0.0001 8.9667% 7.5044% < 0.0001 8.9201%
Buried (All Sites) 40.4969% < 0.0001 47.3970% 38.8245% < 0.0001 48.3826%
Exposed (All Sites) 59.5031% < 0.0001 52.6030% 61.1755% < 0.0001 51.6174%
  1. The distribution of substituted sites by secondary structure and solvent accessibility binned by the nautre of selection are shown. Bolded items are significant (p < 0.00167 after multiple comparisons correction) based on parametric bootstrapping, n = 20000