Table 5 Domains absent in lineages under positive selection
Under-Represented CATH Domain Topologies in TAED | |||||
|---|---|---|---|---|---|
CATH domain topology | Mapped Lineages Under Positive Selection | Lineages Under Positive Selection Mapped | Uncorrected P-value | FDR P-value | Bonferroni P-value |
Smad3 Chain A | 0.08% | <  0.01% | <  0.0001 | <  0.0001 | <  0.0001 |
A middle domain of Talin 1 | 0.24% | <  0.01% | <  0.0001 | <  0.0001 | <  0.0001 |
Endonuclease - Pi-scei_ Chain A domain 1 | 0.27% | <  0.01% | <  0.0001 | <  0.0001 | <  0.0001 |
Undecaprenyl pyrophosphate synthetase | 0.33% | <  0.01% | <  0.0001 | <  0.0001 | <  0.0001 |
Neurophysin II Chain A | 0.38% | <  0.01% | <  0.0001 | <  0.0001 | 0.0002 |
Major Prion Protein | 0.43% | <  0.01% | <  0.0001 | <  0.0001 | 0.0010 |
Archaeosine Trna-guanine Transglycosylase Chain: A domain 4 | 0.45% | <  0.01% | <  0.0001 | <  0.0001 | 0.0023 |
Translation Eukaryotic Peptide Chain Release Factor Subunit 1 Chain A | 0.52% | <  0.01% | <  0.0001 | 0.0002 | 0.0140 |
PWI domain | 0.53% | <  0.01% | <  0.0001 | 0.0003 | 0.0206 |
copper amine oxidase-like fold | 0.57% | <  0.01% | 0.0001 | 0.0005 | 0.0472 |
ERH-like fold | 0.58% | <  0.01% | 0.0001 | 0.0007 | 0.0608 |
Smad Anchor For Receptor Activation Chain B | 0.61% | <  0.01% | 0.0002 | 0.0010 | 0.1011 |
protein kinase ck2 holoenzyme chain C domain 1 | 0.61% | <  0.01% | 0.0002 | 0.0010 | 0.1011 |
Elongin C Chain C domain 1 | 0.65% | <  0.01% | 0.0003 | 0.0017 | 0.1785 |
Conserved hypothetical protein from pyrococcus furiosus pfu- 392,566-001 ParB domain | 0.90% | <  0.01% | 0.0042 | 0.0195 | 1.0000 |
titin filament fold | 0.92% | <  0.01% | 0.0048 | 0.0214 | 1.0000 |
Transcription Regulator spoIIAA | 0.98% | <  0.01% | 0.0073 | 0.0311 | 1.0000 |
cAMP-dependent Protein Kinase Chain A | 0.36% | <  0.01% | <  0.0001 | <  0.0001 | <  0.0001 |
Inorganic Pyrophosphatase | 0.45% | <  0.01% | <  0.0001 | <  0.0001 | <  0.0001 |
subunit c (vma5p) of the yeast v-atpase domain 2 | 0.51% | <  0.01% | <  0.0001 | <  0.0001 | <  0.0001 |
Deoxyuridine 5′-Triphosphate Nucleotidohydrolase_ Chain A | 0.88% | <  0.01% | <  0.0001 | 0.0002 | 0.0135 |
50s Ribosomal Protein L19e Chain O domain 1 | 0.96% | <  0.01% | 0.0001 | 0.0005 | 0.0451 |
Glutathione Synthetase Chain A domain 3 | 1.15% | <  0.01% | 0.0006 | 0.0031 | 0.3377 |
Deoxyhypusine Synthase | 1.18% | <  0.01% | 0.0007 | 0.0037 | 0.4263 |
DNA Excision Repair Uvrb Chain A | 1.29% | <  0.01% | 0.0017 | 0.0084 | 1.0000 |