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Table 4 Domains present in lineages under positive selection

From: Characterizing lineage-specific evolution and the processes driving genomic diversification in chordates

Over-Represented CATH Domain Topologies in TAED
CATH domain topology Mapped Lineages Under Positive Selection Lineages Under Positive Selection Mapped Uncorrected P-value FDR P-value Bonferroni P-value
Rossmann fold 7.35% 25.55% <  0.0001 <  0.0001 <  0.0001
Jelly Rolls 7.30% 4.43% <  0.0001 <  0.0001 0.0013
Phosphorylase Kinase domain 1 9.51% 3.87% <  0.0001 <  0.0001 <  0.0001
TIM Barrel 7.52% 3.59% <  0.0001 <  0.0001 <  0.0001
Thrombin subunit H 11.13% 2.90% <  0.0001 <  0.0001 <  0.0001
Ubiquitin-like (UB roll) 7.06% 2.50% 0.0143 0.0355 1.0000
Glutaredoxin 9.53% 2.39% <  0.0001 <  0.0001 <  0.0001
Collagenase (Catalytic Domain) 9.70% 2.22% <  0.0001 <  0.0001 <  0.0001
DNA polymerase domain 1 8.26% 2.12% <  0.0001 <  0.0001 <  0.0001
OB fold (Dihydrolipoamide Acetyltransferase E2P) 7.32% 1.79% 0.0013 0.0039 0.8113
Methane Monooxygenase Hydroxylase Chain G domain 1 8.24% 1.55% <  0.0001 <  0.0001 <  0.0001
Cytochrome p450 9.11% 1.51% <  0.0001 <  0.0001 <  0.0001
Helicase Ruva Protein domain 3 9.86% 1.21% <  0.0001 <  0.0001 <  0.0001
Laminin 8.56% 1.03% <  0.0001 <  0.0001 <  0.0001
Glutathione S-transferase Yfyf (Class Pi) Chain A domain 2 10.79% 1.01% <  0.0001 <  0.0001 <  0.0001
Kinesin 8.47% 1.00% <  0.0001 <  0.0001 <  0.0001
Glycosyltransferase 12.75% 0.92% <  0.0001 <  0.0001 <  0.0001
FAD/NAD(P)-binding domain 10.68% 0.87% <  0.0001 <  0.0001 <  0.0001
2-enoyl-CoA Hydratase Chain A domain 1 14.07% 0.80% <  0.0001 <  0.0001 <  0.0001
Erythroid Transcription Factor GATA-1 Chain A 9.34% 0.72% <  0.0001 <  0.0001 <  0.0001
Cyclin A domain 1 10.32% 0.71% <  0.0001 <  0.0001 <  0.0001
Alkaline Phosphatase subunit A 9.96% 0.69% <  0.0001 <  0.0001 <  0.0001
Butyryl-CoA Dehydrogenase subunit A domain 3 9.13% 0.68% <  0.0001 <  0.0001 <  0.0001
Carbonic Anhydrase II 14.52% 0.66% <  0.0001 <  0.0001 <  0.0001
  1. Enrichment analysis of CATH domain topologies in TAED showing CATH domains topologies present in highest % of lineages under positive selection. All pathways were significant at the 0.05 level after correction with the false discovery rate (FDR). Bold numbers indicate not significant at the 0.05 level. Lineages with dN/dS > 1 considered under positive selection