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Table 2 Pathways present in lineages under positive selection

From: Characterizing lineage-specific evolution and the processes driving genomic diversification in chordates

Over-Represented KEGG Pathways TAED
KEGG Pathway Mapped Lineages Under Positive Selection Lineages Under Positive Selection Mapped Uncorrected P-value FDR P-value Bonferroni P-value
Metabolic pathways 7.63% 5.73% <  0.0001 <  0.0001 <  0.0001
Olfactory transduction 12.25% 2.67% <  0.0001 <  0.0001 <  0.0001
Biosynthesis of secondary metabolites 7.85% 1.90% <  0.0001 <  0.0001 <  0.0001
Biosynthesis of antibiotics 7.96% 1.11% <  0.0001 <  0.0001 <  0.0001
Neuroactive ligand-receptor interaction 6.45% 1.05% <  0.0001 <  0.0001 <  0.0001
Microbial metabolism in diverse environments 7.86% 0.85% <  0.0001 <  0.0001 <  0.0001
Protein processing in endoplasmic reticulum 6.97% 0.72% <  0.0001 <  0.0001 <  0.0001
Purine metabolism 6.63% 0.69% <  0.0001 <  0.0001 <  0.0001
Herpes simplex infection 6.18% 0.68% 0.0047 0.0128 1.0000
Carbon metabolism 8.63% 0.62% <  0.0001 <  0.0001 <  0.0001
RNA transport 6.45% 0.59% <  0.0001 <  0.0001 0.0056
Influenza A 6.74% 0.59% <  0.0001 <  0.0001 <  0.0001
Fluid shear stress and atherosclerosis 6.21% 0.54% 0.0061 0.016 1.0000
Lysosome 6.72% 0.52% <  0.0001 <  0.0001 <  0.0001
Glycerophospholipid metabolism 7.61% 0.49% <  0.0001 <  0.0001 <  0.0001
Non-alcoholic fatty liver disease (NAFLD) 6.19% 0.47% 0.0128 0.0325 1.0000
Pancreatic secretion 8.86% 0.43% <  0.0001 <  0.0001 <  0.0001
Peroxisome 7.37% 0.42% <  0.0001 <  0.0001 <  0.0001
Toxoplasmosis 6.50% 0.41% 0.0001 0.0003 0.0341
Phosphatidylinositol signaling system 6.70% 0.41% <  0.0001 <  0.0001 0.0004
Glycerolipid metabolism 10.21% 0.39% <  0.0001 <  0.0001 <  0.0001
Drug metabolism - cytochrome P450 12.03% 0.39% <  0.0001 <  0.0001 <  0.0001
Th17 cell differentiation 6.38% 0.38% 0.0013 0.0039 0.4944
Valine_ leucine and isoleucine degradation 11.00% 0.38% <  0.0001 <  0.0001 <  0.0001
Chemical carcinogenesis 9.32% 0.38% <  0.001 <  0.0001 <  0.0001
  1. The top 25 over-represented KEGG pathways with the highest % of lineages under positive selection mapping to a pathway. All pathways were significant at the 0.05 level after correction with the false discovery rate (FDR). Bold numbers indicate not significant at the 0.05 level. Lineages with dN/dS > 1 considered under positive selection