Skip to main content

Table 2 Pathways present in lineages under positive selection

From: Characterizing lineage-specific evolution and the processes driving genomic diversification in chordates

Over-Represented KEGG Pathways TAED

KEGG Pathway

Mapped Lineages Under Positive Selection

Lineages Under Positive Selection Mapped

Uncorrected P-value

FDR P-value

Bonferroni P-value

Metabolic pathways

7.63%

5.73%

<  0.0001

<  0.0001

<  0.0001

Olfactory transduction

12.25%

2.67%

<  0.0001

<  0.0001

<  0.0001

Biosynthesis of secondary metabolites

7.85%

1.90%

<  0.0001

<  0.0001

<  0.0001

Biosynthesis of antibiotics

7.96%

1.11%

<  0.0001

<  0.0001

<  0.0001

Neuroactive ligand-receptor interaction

6.45%

1.05%

<  0.0001

<  0.0001

<  0.0001

Microbial metabolism in diverse environments

7.86%

0.85%

<  0.0001

<  0.0001

<  0.0001

Protein processing in endoplasmic reticulum

6.97%

0.72%

<  0.0001

<  0.0001

<  0.0001

Purine metabolism

6.63%

0.69%

<  0.0001

<  0.0001

<  0.0001

Herpes simplex infection

6.18%

0.68%

0.0047

0.0128

1.0000

Carbon metabolism

8.63%

0.62%

<  0.0001

<  0.0001

<  0.0001

RNA transport

6.45%

0.59%

<  0.0001

<  0.0001

0.0056

Influenza A

6.74%

0.59%

<  0.0001

<  0.0001

<  0.0001

Fluid shear stress and atherosclerosis

6.21%

0.54%

0.0061

0.016

1.0000

Lysosome

6.72%

0.52%

<  0.0001

<  0.0001

<  0.0001

Glycerophospholipid metabolism

7.61%

0.49%

<  0.0001

<  0.0001

<  0.0001

Non-alcoholic fatty liver disease (NAFLD)

6.19%

0.47%

0.0128

0.0325

1.0000

Pancreatic secretion

8.86%

0.43%

<  0.0001

<  0.0001

<  0.0001

Peroxisome

7.37%

0.42%

<  0.0001

<  0.0001

<  0.0001

Toxoplasmosis

6.50%

0.41%

0.0001

0.0003

0.0341

Phosphatidylinositol signaling system

6.70%

0.41%

<  0.0001

<  0.0001

0.0004

Glycerolipid metabolism

10.21%

0.39%

<  0.0001

<  0.0001

<  0.0001

Drug metabolism - cytochrome P450

12.03%

0.39%

<  0.0001

<  0.0001

<  0.0001

Th17 cell differentiation

6.38%

0.38%

0.0013

0.0039

0.4944

Valine_ leucine and isoleucine degradation

11.00%

0.38%

<  0.0001

<  0.0001

<  0.0001

Chemical carcinogenesis

9.32%

0.38%

<  0.001

<  0.0001

<  0.0001

  1. The top 25 over-represented KEGG pathways with the highest % of lineages under positive selection mapping to a pathway. All pathways were significant at the 0.05 level after correction with the false discovery rate (FDR). Bold numbers indicate not significant at the 0.05 level. Lineages with dN/dS > 1 considered under positive selection