The evolution of the huntingtin-associated protein 40 (HAP40) in conjunction with huntingtin

Table 2 Conservation of amino acid residues involved in the interaction of HAP40 with HTT

Protein	Amino acid residue	Normalized conservation score	Confidence Interval
HAP40	E316	0.927	− 0.002; 1,599
	E317	0.011	− 0.701; 0.570
	E331	− 1.104	− 1.658; − 0.786
	D333	− 1.219	− 1.658; − 0.955
HTT	K1967	0.169	− 0.574; 0.732
	K1968	0.442	− 0.307,0.946
	R1998	− 0.467	− 1.047; − 0.106
	R2002	1.007	0.122; 1.549
	R2047	− 1.148	− 1.533; − 0.894

Conservation of amino acid residues involved in the interaction of HAP40 with HTT. Results of ConSurf analysis for selected amino acid residues which were postulated by Guo et al. [11] to be involved in the HAP40-HTT interaction

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