From: The evolution of the huntingtin-associated protein 40 (HAP40) in conjunction with huntingtin
Protein | Protein domain | Positions | Conservation score (mean ± SEM) |
---|---|---|---|
HAP40 | N-terminal domain | 1 − 216 | − 0.14 ± 0.07 |
Central proline-rich region | 217 − 258 | 0.80 ± 0.12 | |
C-terminal domain | 259 − 371 | − 0.03 ± 0.09 | |
HTT | N-HEAT | 91 − 1684 | − 0.09 ± 0.02 |
Insertion | 400 − 674 | 0.48 ± 0.06 | |
N-HEAT without insertion | 91 − 399 + 675 − 1684 | − 0.20 ± 0.03 | |
C-HEAT | 2092 − 3098 | 0.35 ± 0.05 | |
C-HEAT without insertions | 2092 − 2120 + 2457 − 2509 + 2664 − 3098 | − 0.45 ± 0.03 | |
Insertion 1 | 2121 − 2456 | 0.59 ± 0.06 | |
Insertion 2 | 2510 − 2663 | − 0.07 ± 0.07 | |
Bridge | 1685 − 2091 | − 0.05 ± 0.05 |