Fig. 4

Evolutionary conservation of HAP40 (a) and HTT (b): Conservation scores were estimated based on a multiple sequence alignment of HAP40 and HTT orthologs from representative species. For the estimation, the ConSurf method [61, 62] with a Bayesian model [4] and the Jones-Taylor-Thornton model [70] was used. Only amino acids that were resolved by Guo et al. [11] (protein database identifier 6EZ8) are shown in the figure