Fig. 1

Phylogenetic tree of HAP40 (a) and HTT (b). The multiple sequence alignments of HAP40 or HTT orthologs were computed using the MUSCLE algorithm [51, 52] implemented in the MEGA X software [53] as described in the methods section. Phylogenetic trees were calculated by Bayesian inference in MrBayes [55] using Yang’s autocorrelated gamma model [56] and a mixed evolutionary model