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Table 1 A list of the sand rat genes that encode the most aberrantly divergent sand rat proteins ordered by ranking, whether these genes are in GC-rich regions, dSws value and a short description of the function of their encoded protein

From: Divergent genes in gerbils: prevalence, relation to GC-biased substitution, and phenotypic relevance

Rank Gene GC-rich region Sand rat dSws value Encoded protein
1 Pdx1 Yes 20.09 Pancreatic duodenal homeobox. Transcription factor involved in pancreas development and β-cell function.
2 Medag Yes 3.09 Mesenteric estrogen dependent adipogenesis. Involved in adipocyte differentiation and glucose uptake.
3 Pex11g Yes 4.58 Peroxisomal membrane protein. Involved in growth and division of peroxisomes (organelles partaking in lipid biosynthesis).
4 Tex45 Yes 1.48 Testis-expressed protein. Understudied gene expressed in testis.
5 Cblc No 0.60 E3 ubiquitin-protein ligase. Involved in protein degradation; down-regulates receptor-tyrosine kinase (RTK) signaling.
6 Insr Yes 7.08 Insulin receptor. RTK receptor involved in insulin signaling and stimulation of glucose uptake.
7 Trappc5 Yes 34.40 Trafficking protein particle complex subunit. Implicated in vesicular transport from ER to Golgi.
8 Pan3 Yes 10.66 Subunit of PAN2-PAN3 deadenylase complex. Trims poly(A) tail prior to degradation.
9 B3glct Yes 2.29 Beta 3-glucosyltransferase. Transfers glucose onto fucose on TSR repeat proteins.
10 Spp1 No 0.22 Secreted phosphoprotein 1 or osteopontin. Implicated in bone mineralization, immune system, and diet-induced insulin resistance.