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Fig. 3 | BMC Evolutionary Biology

Fig. 3

From: Molecular evolutionary and structural analysis of human UCHL1 gene demonstrates the relevant role of intragenic epistasis in Parkinson’s disease and other neurological disorders

Fig. 3

Structural evolution of UCHL1 protein. a Structural divergence of human UCHL1 after the split from placental mammals common ancestor. One primate specific substitution has occurred which is retained in simians and apes after they diverged from the placental mammalian ancestor. Whereas, three substitutions have occurred specifically at the root of simians lineage and one apes specific substitution is also detected. Structural deviations among ancestors are examined by RMSD values. b Annotated structure of wild type UCHL1. c Superimposed placental mammals ancestor and primates ancestor structures. d Superimposed primates ancestor and simians ancestor structures. e Superimposed simians ancestor and apes ancestor/human structures. Deviated residues in terms of backbone torsion angles (Φ°, Ψ°) are represented in red color and all superimposed structures are color coded

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BMC Ecology and Evolution

ISSN: 2730-7182

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