Table 5 Results of Global Linkage Disequilibrium (GLD) significance test (PRS resampling procedure) between different pairs of MHC loci in chimpanzees (BPRC cohort) and humans (multiple populations, further subdivided into RGD and SGD populations)
| Â | Chimpanzees | Humans | ||||||
|---|---|---|---|---|---|---|---|---|
BPRCWB | Multiple populations | RGD | SGD | |||||
Loci pairs | N | p | k | % significant results (after correction) | k1 | % significant results (after correction) | k2 | % significant results (after correction) |
DPB1 ~ DQB1 | 25 | 0.106 | 40 | 30 (12.5) | 15 | 47 (27) | 25 | 24 (4) |
DPB1 ~ DQA1 | 25 | 0.0697 | 33 | 27.3 (15.1) | 16 | 44 (25) | 17 | 12 (5.9) |
DPB1 ~ DRB1 | 25 | 0.328 | 31 | 25.8 (9.7) | 16 | 37 (12.5) | 15 | 13 (6.7) |
DPB1 ~ B | 25 | 1 | 10 | 10 (10) | 4 | 25 (25) | 6 | 0 |
DPB1 ~ C | 25 | 0.999 | 8 | 12.5 (0) | 2 | 50 (0) | 6 | 0 |
DPB1 ~ A | 24 | 0.982 | 12 | 0 | 5 | 0 | 7 | 0 |
DQB1 ~ DQA1 | 29 | <  10−4 | 46 | 97.8 (97.8) | 20 | 95 (95) | 26 | 100 (100) |
DQB1 ~ DRB1 | 29 | <  10−4 | 51 | 94.1 (94.1) | 23 | 96 (96) | 28 | 93 (93) |
DQB1 ~ B | 29 | 1 | 13 | 61.5 (53.8) | 7 | 86 (86) | 6 | 33 (16.7) |
DQB1 ~ C | 29 | 0.975 | 10 | 40 (40) | 5 | 60 (60) | 5 | 20 (20) |
DQB1 ~ A | 28 | 0.98 | 16 | 12.5 (12.5) | 9 | 22 (22) | 7 | 0 |
DQA1 ~ DRB1 | 29 | <  10−4 | 38 | 97.4 (97.4) | 21 | 100 (100) | 17 | 94 (94) |
DQA1 ~ B | 29 | 1 | 9 | 44.4 (44.4) | 5 | 80 (80) | 4 | 0 |
DQA1 ~ C | 29 | 1 | 6 | 33.3 (33.3) | 3 | 67 (67) | 3 | 0 |
DQA1 ~ A | 28 | 0.831 | 12 | 8.3 (0) | 7 | 14 (0) | 5 | 0 |
DRB1 ~ B | 29 | 1 | 39 | 51.3 (35.9) | 22 | 73 (54.5) | 17 | 23 (11.8) |
DRB1 ~ C | 29 | 0.998 | 30 | 63.3 (63.3) | 18 | 78 (78) | 12 | 42 (42) |
DRB1 ~ A | 28 | 0.991 | 39 | 28.2 (25.6) | 24 | 33 (33) | 15 | 20 (13.3) |
B ~ C | 29 | 0.0001 | 59 | 74.6 (74.6) | 21 | 95 (95) | 38 | 63 (63) |
B ~ A | 28 | 0.931 | 76 | 35.5 (25) | 27 | 63 (40.7) | 49 | 20 (16.3) |
C ~ A | 28 | 0.892 | 58 | 53.4 (37.9) | 23 | 65 (47.8) | 35 | 46 (31.4) |