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Table 3 Genetic diversity at 7 MHC loci in chimpanzees (average on all chimpanzee cohorts and in the pooled cohort) and human populations (averaged on multiple populations)

From: Similar patterns of genetic diversity and linkage disequilibrium in Western chimpanzees (Pan troglodytes verus) and humans indicate highly conserved mechanisms of MHC molecular evolution

  Number of samples (k) & sample size (N) Allelic richness (ar) Heterozygosity (H) Nucleotide diversity (П)
Chimpanzees Humans Chimpanzees Humans Chimpanzees Humans Chimpanzees Humans
average pooleda average pooleda average pooleda
k NP k \( \overline{N} \)(s.d) \( \overline{ar\ } \)(s.d) arP \( \overline{ar} \)P (s.d) \( \overline{H}\% \)(s.d) HP% \( \overline{H}\% \)(s.d) \( \overline{\varPi} \)x 10-2 (s.d) ПP x 10-2 \( \overline{\varPi} \)x 10-2 (s.d)
DPB1 2 44 50 87.8 (45.2) 6.3 (1.8) 7.4 9.8 (3.7) 77.9 (0.4) 80.3 72.5 (17.1) 1.3 (0.1) 1.3 2.4 (0.9)
DQB1 3 48 79 100.6 (55.3) 5.0* (0.9) 5.6 9.6 (3.2) 63.7* (13.8) 55.8 79 (11.2) 4.0* (0.3) 3.9 6.0 (1.6)
DQA1 1 29 52 90.6 (45.5) 5 (-) 5 6.4 (1.6) 71.5 (-) 71.5 74.3 (10.9) 7.8 (-) 7.8 6.9 (1.3)
DRB1 3 46 89 105.5 (111.8) 10.1 (2.6) 9.7 14.3 (5.3) 84.7 (3.8) 84.6 86.4 (8.3) 8.1 (1.1) 7.0 7.0 (1.2)
B 3 51 80 124 (134.6) 13.9 (3.5) 17.1 19.2 (7.1) 84.1 (3.9) 86.4 90.3 (6.8) 5.0* (0.5) 5.2 4.2 (0.5)
C 2 51 59 127.9 (141.1) 9.7 (3.2) 11.5 12.4 (4.2) 79.6 (4.3) 81 85.2 (7.4) 2.1* (0.2) 2.1 2.6 (0.2)
A 3 50 81 127.6 (133.6) 13 (0.9) 14.2 11.9 (5.2) 88.6 (1.2) 90.3 79.7 (15.4) 2.7* (0.3) 2.7 3.4 (0.5)
  1. k: number of samples; Np: size of pooled cohort; \( \overline{N} \)(s.d): average size of human population samples and standard deviation
  2. \( \overline{ar} \)(s.d): average allelic richness in the chimpanzee samples and standard deviation; arP: allelic richness of the pooled cohort; \( \overline{ar} \)P (s.d): average allelic richness in human population samples (estimated relatively to the pooled cohort) and standard deviation. * value (in bold) significantly different between human populations and chimpanzee cohorts (Wilcoxon test, p = 0.0342) for allelic richness at DQB1. Test without the Texascb cohort: Wilcoxon two-sided test: p = 0.0604, single-sided test (“less”): p = 0.0302
  3. \( \overline{H}\% \)(s.d): average expected heterozygosity in the chimpanzee samples and in human population samples and standard deviation; HP%: expected heterozygosity of the pooled cohort. * value (in bold) significantly different between human populations and chimpanzee cohorts (Wilcoxon test, p = 0.0316) for heterozygosity at DQB1. Test without the Texascb cohort: Wilcoxon two-sided test: p = 0.0371, single-sided test (“less”): p = 0.0185
  4. \( \overline{\varPi} \)(s.d): average expected nucleotide diversity in the chimpanzee samples and in human population samples and standard deviation; ПP: expected nucleotide diversity of the pooled cohort. * values (in bold) significantly different between human populations and chimpanzee cohorts (Wilcoxon test, p = 0.0426, 0.0175, 0.0225,0.0371) for nucleotide diversity at DQB1, B, C and A, respectively. Test without the Texascb cohort: Wilcoxon two-sided test: p = 0.0825, 0.0255, 0.0944, single-sided test: p = 0.0412, 0.0128, 0.0472 at DQB1, B and A, respectively
  5. The order of loci corresponds to their position on the chromosome from centromere (top) to telomere (bottom)
  6. adoes not include Texascb (see Text)