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Table 1 Results of Hardy-Weinberg equilibrium (HWE) and Ewens-Watterson-Slatkin (EWS) tests at seven MHC loci in chimpanzees (pooled cohort) and humans (multiple populations)

From: Similar patterns of genetic diversity and linkage disequilibrium in Western chimpanzees (Pan troglodytes verus) and humans indicate highly conserved mechanisms of MHC molecular evolution

Chimpanzees (pooled cohort) DPB1 DQB1 DQA1 DRB1 B C A
N 44 48 29 46 51 51 50
HWE p-value 1 0.456 0.627 0.81 0.983 0.226 1
EWS p-value (excess heterozygotes) 0.079 0.873 0.100 0.031 0.645 0.811 0.069
EWS p-value (excess homozygotes) 0.491 0.970 0.707 0.473 0.907 0.945 0.572
Humans (multiple populations) DPB1 DQB1 DQA1 DRB1 B C A
k 50 79 52 89 80 59 81
\( \overline{N} \)(s.d) 87.8 (45.2) 100.6 (55.3) 90.7 (45.5) 105.5 (111.8) 124 (134.6) 127.9 (141.1) 127.6 (133.6)
% HWE rejections (after correction) 0 0 0 1.1 (0) 0 0 0
% EWS rejections (excess heterozygotes) 0 16.46 (2.5) 28.84 (0) 30.34 (7.9) 30 (0) 33.9 (0) 16.05 (3.7)
% EWS rejections (excess homozygotes) 22 (2) 1.27 (0) 0 2.25 (0) 5 (0) 1.69 (0) 7.41 (0)
  1. N: sample size (in number of individuals); k: number of populations; \( \overline{N} \): mean sample size (in number of individuals); s.d.: standard deviation; Holm correction for multiple testing is given within brackets for the % of HWE and EWS tests. Significance tests were done without prior assumptions, thus two-tailed rejection at the 5% level either occurs below 0.025 (excess of heterozygotes) or above 0.975 (excess of homozygotes). The order of loci corresponds to their position on the chromosome from centromere (left) to telomere (right). The pooled cohort does not include Texascb (see Text)