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Table 1 Families with the most pervasive recurrent sequence evolution (P≥12)

From: Recurrent sequence evolution after independent gene duplication

P

Fate ‘yellow’

Fate ‘blue’

Common denominator

Potential differentiation

20

eef-1B.1 (Cele)

eef-1B.2 (Cele)

elongation factor

-

19

cka1 (Scer)

cka2 (Scer)

casein kinase II, catalytic subunit

i.a. Specific protein interactions [36]

19

vma11 (Scer)

vma3 (Scer)

V-ATPase subunit

Complementary loss of interaction interfaces [34]

18

ercc3 (Gthe)

unknown

TFIIH subunit XPB

-

17

Hspa2

Hspa8

heat-shock protein

Constitutive vs. heat-induced expression [30]

16

RpIIIc160 (Dmel)

unknown

DNA-directed RNA polymerase subunit

-

15

Rrm2

Rrm2b

ribonucleotide reductase regulatory subunit

Complexes specialized to cell-cycle progression vs. DNA repair [35]

15

Sphk1

Sphk2

sphingosine kinase

Antagonists in sphingolipid metabolism? [37].

15

eno1 (Xtro)

eno4 (Xtro)

enolase

-

14

aspS1 (Ddis)

aspS2 (Ddis)

aspartate–tRNA ligase

-

14

unknown

unknown

ethanolaminophosphotransferase

-

13

Senp6

Senp7

sentrin-specific protease

Some substrate specificity and differences in catalytic activity [38]

13

Mpdu1

Pqlc3

∼ cargo receptors

-

13

unknown

unknown

isoleucine–tRNA ligase

-

13

Hars

Hars2

histidine–tRNA ligase

Cytoplasmic vs. mitochondrial specialization [32]

12

rpa1 (Gthe)

rpa1 (Gthe)

replication protein A1

-

12

unknown

unknown

cystinosin

-

12

nmd3 (Gthe)

nmd3 (Gthe)

60S ribosomal export protein NMD3

-

12

Sco1

Sco2

synthesis of cytochrome c oxidase

-

12

cycs (Xtro)

cyct (Xtro)

cytochrome c

Somatic vs. testis-specific in animals [39]

12

aimp1 (Drer)

aimp1 (Drer)

ARS-interacting multifunctional proteina

-

12

psenA (Ddis)

psenB (Ddis)

presinilin

-

  1. aARS: aminoacyl-tRNA synthetase complex
  2. For each family we display P, two representative genes from each fate, their united functional annotation and their potential functional differentiation based on the literature. Human names start with a capital; other organisms are given in brackets (Cele: Caenorhabditis elegans, Scer: Saccharomyces cerevisiae, Xtro: Xenopus tropicalis, Ddis: Dictyostelium discoideum, Drer: Danio rerio, Dmel: Drosophila melanogaster, Gthe: Guillardia theta)