Skip to main content

Table 1 Families with the most pervasive recurrent sequence evolution (P≥12)

From: Recurrent sequence evolution after independent gene duplication

P Fate ‘yellow’ Fate ‘blue’ Common denominator Potential differentiation
20 eef-1B.1 (Cele) eef-1B.2 (Cele) elongation factor -
19 cka1 (Scer) cka2 (Scer) casein kinase II, catalytic subunit i.a. Specific protein interactions [36]
19 vma11 (Scer) vma3 (Scer) V-ATPase subunit Complementary loss of interaction interfaces [34]
18 ercc3 (Gthe) unknown TFIIH subunit XPB -
17 Hspa2 Hspa8 heat-shock protein Constitutive vs. heat-induced expression [30]
16 RpIIIc160 (Dmel) unknown DNA-directed RNA polymerase subunit -
15 Rrm2 Rrm2b ribonucleotide reductase regulatory subunit Complexes specialized to cell-cycle progression vs. DNA repair [35]
15 Sphk1 Sphk2 sphingosine kinase Antagonists in sphingolipid metabolism? [37].
15 eno1 (Xtro) eno4 (Xtro) enolase -
14 aspS1 (Ddis) aspS2 (Ddis) aspartate–tRNA ligase -
14 unknown unknown ethanolaminophosphotransferase -
13 Senp6 Senp7 sentrin-specific protease Some substrate specificity and differences in catalytic activity [38]
13 Mpdu1 Pqlc3 cargo receptors -
13 unknown unknown isoleucine–tRNA ligase -
13 Hars Hars2 histidine–tRNA ligase Cytoplasmic vs. mitochondrial specialization [32]
12 rpa1 (Gthe) rpa1 (Gthe) replication protein A1 -
12 unknown unknown cystinosin -
12 nmd3 (Gthe) nmd3 (Gthe) 60S ribosomal export protein NMD3 -
12 Sco1 Sco2 synthesis of cytochrome c oxidase -
12 cycs (Xtro) cyct (Xtro) cytochrome c Somatic vs. testis-specific in animals [39]
12 aimp1 (Drer) aimp1 (Drer) ARS-interacting multifunctional proteina -
12 psenA (Ddis) psenB (Ddis) presinilin -
  1. aARS: aminoacyl-tRNA synthetase complex
  2. For each family we display P, two representative genes from each fate, their united functional annotation and their potential functional differentiation based on the literature. Human names start with a capital; other organisms are given in brackets (Cele: Caenorhabditis elegans, Scer: Saccharomyces cerevisiae, Xtro: Xenopus tropicalis, Ddis: Dictyostelium discoideum, Drer: Danio rerio, Dmel: Drosophila melanogaster, Gthe: Guillardia theta)