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Fig. 5 | BMC Evolutionary Biology

Fig. 5

From: Clonal evolution driven by superdriver mutations

Fig. 5

Comparison between simulated waiting times and the theoretical sum approximation. a We examined how the expected waiting time τkℓ to k superdrivers and drivers, as calculated from the sum of the individual waiting times (dashed), agree with the empirical waiting times from the simulations (solid). While for lower k and the agreement is generally high, the agreement decreases as k and increase. b Improved waiting time approximation, particularly for higher k and . We modeled the deviation between the simulated waiting times and the analytically approximated waiting times using a regression model with driver fitness, superdriver factor, and numbers of driver and superdriver mutations to wait for as covariates. The regression revealed that driver fitness parameter was the predictor with the largest effect size

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