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Fig. 2 | BMC Evolutionary Biology

Fig. 2

From: The origins and developments of sulfation-prone tyrosine-rich and acidic N- and C-terminal extensions of class ll and lll small leucine-rich repeat proteins shed light on connective tissue evolution in vertebrates

Fig. 2

Alignments of class II SLRPs reveal the molecular evolution of their terminal regions. The upper panel in each subfigure contains representative sequences of the N-terminal regions of class II SLRPs from the class II SLRP MSAs (Additional file 1) starting from the first amino acid (position 1) after the signal peptide and ending at the first conserved cysteine. For the osteoadherin C-terminal region, the area starting from position 368 to the end of the MSA at position 437 is represented. Lower panels contain sequence logo representations of the N- or C-terminal regions of each class II SLRP. Description of the residue colour coding can be found in the methods section. a: Fibromodulin representative sequences and sequence logo of amniote sequences (63 sequences). b: Lumican representative sequences and sequence logo of jawed vertebrate sequences (95 sequences). A degree of variation in the amino acid composition and length of the N-terminal region of lumican in different taxonomic genera is evident from the gaps introduced in the MSA. c: Representative sequences of the N-terminal region of osteoadherin and sequence logo of bony vertebrate sequences (38 sequences). d: Representative sequences of the C-terminal region of osteoadherin and sequence logo of tetrapod sequences (34 sequences). e: Keratocan representative sequences and sequence logo of tetrapod sequences (55 sequences). f: PRELP representative sequences and sequence logo of jawed vertebrates sequences (39 sequences). The representative sequences are from Homo sapiens (Q06828; P51884; Q99983; O60938; P51888), Mus musculus (P50608; P51885; O35103; O35367; Q9JK53), Gallus gallus (P51887; P51890; R4GF52; O42235; A0A1D5PAN0), Chelonia mydas (M7AZ87; M7BEH4; XP_007065190.1), Pelodiscus sinensis (K7F6Y3; K7G746), Xenopus tropicalis (F6RIJ3; Q640B1; XP_012817254.1; XP_002937114.2; A4IIL0), Latimeria chalumnae (XP_006002318.1; H2ZW54; XP_005987119.1; XP_014352190.1; H3ADS3), Danio rerio (F1QG51; Q6IQQ7; F6NL91; Q5RI43; F1QY29), Lepisosteus oculatus (W5N2Q9; W5NHY1; W5N8Y0), Scleropages formosus (A0A0P7VL56), Nothobranchius kadleci (A0A1A8BTR3), Rhincodon typus (XP_020392147.1; XP_020368858.1), and Callorhinchus milii (XP_007893500.1; V9NEN7; XP_007893501.1)

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