Fig. 5

Relationship between hierarchical node structure of yeast interactome and evolutionary parameters. Node types are designated as peripheral (P), intermediate (I), or hub (H) based on discriminant function analysis, and nodes that were found to evolve convergently (C; N = 21) in yeasts. Three evolutionary outcomes (a) substitution rate, (b) expression level, approximated through Codon Adaptation Index (CAI), and (c) evolutionary rewiring score significantly differ among node categories (see text). C-node boxes are sorted by Median. Double red line: outliers above median not shown in figure but included in tests. Raw data points - triangles, circles - outliers, stars - extreme values, squares - Medians, boxes - 25-75% data, whiskers - non-outlier range