Fig. 2

TERB1-TERB2-MAJIN proteins share domain architecture organization and functional sites across metazoans. Multiple sequence alignment of the most conserved regions of putative orthologs of mice TERB1 (a), TERB2 (b), and MAJIN (c) from various representative metazoan species with PROMALS3D and annotated using ESPrit 3.0. The threshold for grouping of the residues was set to 70% and is depicted in yellow. Amino acid positions conserved in all taxa are highlighted in red. Species names are shown at the left. The horizontal lines above the alignment indicate domain boundaries. Armadillo repeat; ARM repeat, T2B; binding site of TERB2 and MYB; homeodomain; N-terminal domain (NTD); and C-terminal domain (CTD). The TRF1-binding motif region of mouse TERB1 is highlighted by the violet rectangle. The motif [F/YxLxP] detected in all TERB2 sequences is shown in the dark blue rectangle