Table 5 Selected DEG in Set C for waveform polarity, by “general” functional class and EOD phenotype, and highlights of their expected function
From: The transcriptional correlates of divergent electric organ discharges in Paramormyrops electric fish
NCBI Gene ID | Gene Description | Gene Symbol | “general” functional class | upregulated in phenotype | Highlights of Predicted Function (edited from UniProt) |
|---|---|---|---|---|---|
111840706 | G protein-activated inward rectifier potassium channel 1 | LOC111840706 | Cation homeostasis | Small penetrations | This potassium channel is controlled by G proteins. Plays a crucial role in regulating the heartbeat |
111853690 | protein kinase cGMP-dependent 1 | prkg1 | Cation homeostasis | Small penetrations | Serine/threonine protein kinase. Numerous protein targets for PRKG1 phosphorylation are implicated in modulating cellular calcium. Proteins that are phosphorylated by PRKG1 regulate platelet activation and adhesion, smooth muscle contraction, cardiac function, gene expression |
111843447 | myosin light chain 4-like | LOC111843447 | Cytoskeletal & sarcomeric | Large penetrations | Regulatory light chain of myosin. Does not bind calcium |
111851664 | leucine rich repeat containing 10 | lrrc10 | Cytoskeletal & sarcomeric | Large penetrations | May play important roles in cardiac development and/or cardiac function |
111856907 | Wiskott-Aldrich syndrome protein family member 3-like | LOC111856907 | Cytoskeletal & sarcomeric | Large penetrations | Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape |
111834243 | desmin-like | LOC111834243 | Cytoskeletal & sarcomeric | Small penetrations | Muscle-specific type III intermediate filament essential for proper muscular structure and function. Plays a crucial role in maintaining the structure of sarcomeres. May act as a sarcomeric microtubule-anchoring protein |
111843225 | protein kinase C alpha type-like | LOC111843225 | Cytoskeletal & sarcomeric | Small penetrations | Regulates cardiomyocyte function by phosphorylating cardiac troponin T (TNNT2/CTNT), which induces significant reduction in actomyosin ATPase activity, myofilament calcium sensitivity and myocardial contractility |
111848393 | PH and SEC7 domain-containing protein 1-like | LOC111848393 | Cytoskeletal & sarcomeric | Small penetrations | Induces cytoskeletal remodeling |
111849608 | CDC42 effector protein 3 | cdc42ep3 | Cytoskeletal & sarcomeric | Small penetrations | Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes |
111853190 | protein phosphatase 1 regulatory subunit 12B-like | LOC111853190 | Cytoskeletal & sarcomeric | Small penetrations | Regulates myosin phosphatase activity. Augments Ca2+ sensitivity of the contractile apparatus |
111856340 | calponin-1-like | LOC111856340 | Cytoskeletal & sarcomeric | Small penetrations | Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity |
111856797 | myosin light chain 3-like | LOC111856797 | Cytoskeletal & sarcomeric | Small penetrations | Regulatory light chain of myosin. Does not bind calcium |
111838718 | inter-alpha-trypsin inhibitor heavy chain H5-like | LOC111838718 | Extracellular matrix | Small penetrations | inter-alpha-trypsin inhibitors usually interact with hyaluronan |
111841241 | epiphycan-like | LOC111841241 | Extracellular matrix | Small penetrations | May have a role in bone formation and also in establishing the ordered structure of cartilage through matrix organization |
111844627 | collagen alpha-1(V) chain-like | LOC111844627 | Extracellular matrix | Small penetrations | Type V collagen is a member of group I collagen (fibrillar forming collagen). It is a minor connective tissue component of nearly ubiquitous distribution. Type V collagen binds to DNA, heparan sulfate, thrombospondin, heparin, and insulin |
111853425 | thrombospondin 2 | thbs2 | Extracellular matrix | Small penetrations | Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions |
111854264 | collagen type IX alpha 2 chain | col9a2 | Extracellular matrix | Small penetrations | Structural component of hyaline cartilage and vitreous of the eye |
111857302 | anthrax toxin receptor 1-like | LOC111857302 | Extracellular matrix | Small penetrations | Interacts with extracellular matrix proteins and with the actin cytoskeleton. Mediates adhesion of cells to type 1 collagen and gelatin, reorganization of the actin cytoskeleton and promotes cell spreading |
111857834 | collagen alpha-4(VI) chain-like | LOC111857834 | Extracellular matrix | Small penetrations | Collagen VI acts as a cell-binding protein |
111859912 | cell migration-inducing and hyaluronan-binding protein-like | LOC111859912 | Extracellular matrix | Small penetrations | Mediates depolymerization of hyaluronic acid (HA) via the cell membrane-associated clathrin-coated pit endocytic pathway. Binds to hyaluronic acid |
111834720 | protein EFR3 homolog B-like | LOC111834720 | Lipid metabolism | Large penetrations | Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane. The complex acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns4P) synthesis |
111840084 | cytosolic phospholipase A2-like | LOC111840084 | Lipid metabolism | Small penetrations | Selectively hydrolyzes arachidonyl phospholipids in the sn-2 position releasing arachidonic acid |
111853114 | alkaline ceramidase 2-like | LOC111853114 | Lipid metabolism | Small penetrations | Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid |