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Fig. 1 | BMC Evolutionary Biology

Fig. 1

From: Human-specific mutations in VMAT1 confer functional changes and multi-directional evolution in the regulation of monoamine circuits

Fig. 1

Amino acid sequence and protein structure of VMAT1. a Sequence alignments of VMAT1 among mammalian species show that the two conserved residues (highlighted in red) have changed specifically in humans. b Structure analysis shows that the 130th and 136th residues (highlighted in red) are located at the end of the loop domain between the first (highlighted in blue) and second (highlighted in yellow) transmembrane regions, as previously predicted. The side chains of the residues of interest are displayed in enlarged boxes

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