Fig. 3

Pairwise LD across ~ 10 kbs encompassing LTα and the 5′ region in selected populations. We measured pairwise LD, using the D′ statistic, calculated with Haploview [40], which outputs a graphical representation of allelic associations. In the resulting plots, pairwise LD coefficients D′ × 100 are given in each cell. The color scheme of each cell signifies the strength of association between SNP alleles. Specifically, bright red squares indicate statistically significant LD between SNP pairs (D′ = 100; logarithm of odds (LOD) > 2), while shades of pink/white cells signify little evidence of LD (D′ < 100; LOD < 2) between loci and purple cells signal high LD but with little statistical support (low LOD) [40]. The bold triangles in the plots also indicate strong blocks of LD between SNP markers. The corresponding genomic coordinate for each marker can be found in Additional file 2: Table S10. The genomic region analyzed is given at the top of each plot (exons are labeled 1 through 4)