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Fig. 1 | BMC Evolutionary Biology

Fig. 1

From: Multiple selective sweeps of ancient polymorphisms in and around LTα located in the MHC class III region on chromosome 6

Fig. 1

Gene structure and distribution of variants among major geographic regions. a Gene structure of LTα consists of four exons (yellow shapes) and intervening introns (black horizontal lines). Exons are labeled 1 through 4, and the start-end nucleotide positions for each exon are given in bps. The translation start site (ATG) begins at nucleotide position + 461 in exon 2; the entire LTα coding region is 618 bps in length. Immediately adjacent to the LTα gene is the 5′ regulatory region shown in purple. The combined length of LTα and the 5′ region is 9637 bps; b Venn diagram showing the number of polymorphisms in LTα found in four geographic regions— namely, Africa, South Asia, Europe and East Asia; c Venn diagram showing the number of polymorphisms in the 5′ regulatory region present in the above-mentioned geographic regions. For b and c, the number of polymorphisms shared among geographic regions is given in the interior portions of intersecting ovals, while the number of polymorphisms private to a particular geographic region is given outside of the intersecting ovals. We did not include African American and African Caribbean (Barbadian) populations with indigenous Africans when we examined the continental differences in the number of polymorphisms

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