Comparison of wild-type and mutated structures | Major change in backbone torsion angles (residue number) | Major shift in regions | Critical region |
---|---|---|---|
P33S | 44,45,110,132-135,137,141-143,147–150 | CRD domain |  |
285,417–432 | Seven TMs domain. |  | |
496–537 | K-T-XXX-W, PDZ binding motif |  | |
G36D | 41–46,70,71,133-138,141–150 | CRD domain |  |
416–431,468 | Seven TMs domain. |  | |
495–537 | K-T-XXX-W, PDZ binding motif |  | |
E40Q | 135–144,156–158 | CRD domain |  |
182–186,199, 202 | UCR |  | |
243–244,248,284-286,337-338,417-420,466–469 | Seven TMs domain |  | |
505–537 | PDZ binding motif |  | |
Y58C | 134–135,141-144,147–150 | CRD domain |  |
243–244,248,284-285,334-337,416-431,467-469,495–497 | Seven TMs domain |  | |
508–537 | PDZ binding motif |  | |
H69Y | 147–149 | CRD domain |  |
285,287,334-339,415–432 | Seven TMs domain |  | |
504–537 | K-T-XXX-W, PDZ binding motif |  | |
M105 T | 274–278,284-286,467,468 | Seven TMs domain |  |
506–537 | PDZ binding motif | 495–537 | |
M105 V | 107–114,132–135 | CRD domain |  |
284–286,332-338,416-430,467–469. | Seven TMs domain |  | |
505–537 | PDZ binding motif |  | |
I114T | 15–44,49,62-81,110,118,134–156 | Signal peptide and CRD domain |  |
213–214,274–275 | Seven TMs domain |  | |
495–537 | K-T-XXX-W, PDZ binding motif |  | |
C117R | 49,70-71,73–74 | CRD domain |  |
274–275 | Seven TMs domain |  | |
496–537 | K-T-XXX-W, PDZ binding motif |  | |
R127H | 15–44,49,63-81,110-111,118,133–156 | Signal peptide and CRD domain |  |
173–179 | UCR |  | |
213–214,274–275 | Seven TMs domain |  | |
496–537 | K-T-XXX-W, PDZ binding motif |  | |
M157 V | 133–135,142–151 | CRD domain |  |
284,285,337,338,417-423,428-431,467–470 | Seven TMs domain |  | |
496–537 | K-T-XXX-W, PDZ binding motif |  | |
C181R | 419–422 | Seven TMs domain |  |
503–537 | PDZ binding motif |  | |
C181Y | 420–423 | Seven TMs domain |  |
508–537 | PDZ binding motif |  | |
C204R | 69–72,134,135,144–150 | CRD domain |  |
337,338,418-420,430,431 | Seven TMs domain | Â | |
495–537 | K-T-XXX-W, PDZ binding motif |  | |
C204Y | 66–67,70-71,102,141–150 | CRD domain |  |
243–244,419–420 | Seven TMs domain |  | |
504–537 | K-T-XXX-W, PDZ binding motif |  | |
Y211H | 496–537 | K-T-XXX-W, PDZ binding motif |  |
M223K | 504–537 | K-T-XXX-W, PDZ binding motif |  |
T237R | 214,274–275 | Seven TMs domain |  |
503–537 | K-T-XXX-W, PDZ binding motif |  | |
R253C | 504–537 | K-T-XXX-W, PDZ binding motif |  |
W335C | 274–275 | Seven TMs domain |  |
496–537 | K-T-XXX-W, PDZ binding motif |  | |
A370G | 46–52,68-80,141 | CRD domain |  |
504–537 | K-T-XXX-W, PDZ binding motif |  | |
R417Q | 42–46,147-150,134-137,147–150 | CRD domain |  |
418–432 | Seven TMs domain |  | |
507–537 | PDZ binding motif |  | |
G488D | 41–46,109-114,133–151 | CRD domain |  |
416–432 | Seven TMs domain |  | |
495–537 | K-T-XXX-W, PDZ binding motif |  | |
G488 V | 38,70 | CRD domain |  |
505–537 | PDZ binding motif |  | |
S497F | 70–71,73–74 | CRD domain |  |
503–537 | K-T-XXX-W, PDZ binding motif |  | |
K499E | 147–148 | CRD domain |  |
284–286, 336–338,418–431, 468–470 | Seven TMs domain |  | |
505–537 | K-T-XXX-W, PDZ binding motif |  |