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Table 5 Functional enrichment summary of protein-protein interaction network of proteins evolved with accelerated RSA change rate in Rodentia clade (based on GENEMANIA [55] data)

From: mtProtEvol: the resource presenting molecular evolution analysis of proteins involved in the function of Vertebrate mitochondria

Function Heterotachy model, FDR Heterotachy and Site partitioning models intersection, all data, FDR
All data Protein structure-aware data
oxidoreductase complex 3.89E-30 1.17E-21 5.48E-13
mitochondrial membrane 3.06E-26 3.40E-22 9.94E-13
mitochondrial inner membrane 3.06E-26 7.17E-20 1.25E-11
cellular respiration 3.06E-26 7.00E-21 2.81E-10
NADH dehydrogenase (quinone) activity 1.91E-23 2.33E-24 2.91E-09
mitochondrial respiratory chain complex I 4.80E-23 2.87E-24 3.74E-09
oxidoreductase activity, acting on NAD(P)H, quinone or similar as acceptor 1.15E-21 6.05E-23 1.53E-08
mitochondrion organization 5.79E-10 1.62E-09 1.53E-08
energy derivation by oxidation of organic compounds 1.79E-20 6.56E-16 1.31E-07
mitochondrial electron transport, NADH to ubiquinone 2.02E-21 1.44E-22 1.56E-07
oxidoreductase activity, acting on NAD(P)H 9.36E-19 3.95E-20 2.96E-07
mitochondrial ATP synthesis coupled electron transport 1.79E-20 1.17E-21 3.64E-07
respiratory electron transport chain 2.02E-21 5.28E-21 8.52E-07
oxidative phosphorylation 5.21E-25 2.87E-24 1.57E-06
mitochondrial matrix 1.49E-16 3.74E-06 9.09E-15
regulation of acetyl-CoA biosynthetic process from pyruvate 2.19E-10 4.13E-06
acetyl-CoA biosynthetic process 6.16E-10 7.52E-06
protein targeting to mitochondrion 2.17E-06 2.30E-05
pyruvate metabolic process 4.33E-08 9.78E-05
thioester biosynthetic process 1.29E-07 0.000188
mitochondrial transport 7.79E-06 0.000921