Fig. 2

Examples of inactivating mutations in ODAM. a) Orycteropus afer (aardvark). b) Xenarthra (anteaters, sloths, armadillos). c) Manis spp. (pangolins). d) Cetacea (whales, dolphins, porpoises). Green boxes denote frameshift insertions; blue boxes denote frameshift deletions; and purple boxes denote premature stop codons. Loxodonta, Procavia, Hyaena, Canis, and Hippopotamus have intact ODAM sequences and were included in different alignment panels to provide context for inactivating mutations