Origin and diversification of the plasminogen activation system among chordates

Table 2 Reciprocal best hits (BRBH) to human PLG activator group members in lower chordates

Animal group	Species	BRBH	Protein domain types
Cephalochordates	Branchiostoma belcheri	tPA	SRCR, Kringle, LDLRA, PAN, Trypsin^a
	Branchiostoma belcheri	HABP2	SRCR, Kringle, LDLRA, PAN, Trypsin
	Branchiostoma floridae	HGFAC	SRCR, Kringle, LDLRA, Trypsin^a
	Assymetron lucayanum	HABP2	SRCR, Kringle, LDLRA, PAN, Trypsin
Urochordates	Ciona intestinalis	HABP2	FN2, PAN, Kringle, Trypsin
Urochordates	Oikopleura dioica	HABP2	Kringle, Trypsin

^aindicates Trypsin domain predicted to be non-functional. SRCR (scavenger receptor cysteine-rich domain), LDLRA (Low-density lipoprotein (LDL) receptor class A), FN2 (fibronectin type 2 domain)

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