Fig. 7
From: Origin and diversification of the plasminogen activation system among chordates
Phylogenetic tree of the different proteins containing three LU domains identified in vertebrates and close paralogues. Percentage of bootstrap support after 1000 replicates is shown in each branch. The tree was rooted at the elasmobranch 2 LU branch for convenience in display. a uPAR BRBH in elasmobranchs, b Elephant shark (cartilaginous fish) uPAR BRBH, c BRBH to ray-finned fishes uPAR and PINLYP, coelacanth uPAR and lungfish PINLYP. d Branch containing all the sarcopterygian three-LU genes. Numbers displaying the cysteine pattern of their first, second and third LU domains. e Branch containing human uPAR. uPAR (urokinase-type plasminogen activator receptor), LU (Ly6/uPAR domain), PINLYP (phospholipase A2 inhibitor and LY6/PLAUR domain containing protein), CD177 (cluster of differentiation 177)