Skip to main content
Fig. 2 | BMC Evolutionary Biology

Fig. 2

From: Evolution of vertebrate nicotinic acetylcholine receptors

Fig. 2

The left panel shows a phylogenetic tree based on intron insertions into the vertebrate sequences. The top panel shows a schematic outline of the general protein domain structure, including the extracellular domain (ECD), the binding domain (BD), the transmembrane regions 1–3 (TM1-TM3), the large intracellular domain (ICD) and finally the last TM4 region and the short extracellular carboxy-terminus. The Cys-loop with its conserved proline is marked in yellow. Below follows the exon-intron organization for each gene, if the organization is the same in two or more genes only one of them is shown. The color coding of the exons corresponds to the schematic outline in the top panel. The exons are drawn to scale and the splice phase is indicated at the beginning of each intron. Common intron positions are marked with a line, combining the positions that are identical between the different genes. The introns are numbered (1–20). The curved line indicates a common position shared between the CHRNB1/CHRNB1.2 genes and the CHRNA1 gene. Positions of cysteines, N-linked glycosylation sites (those with the same color are in corresponding positions) and the cysteine pair are also marked for each gene. Faded color means that it is not present in all orthologs

Back to article page
\