TY - JOUR AU - Pedersen, Julia E. AU - Bergqvist, Christina A. AU - Larhammar, Dan PY - 2019 DA - 2019/01/30 TI - Evolution of vertebrate nicotinic acetylcholine receptors JO - BMC Evolutionary Biology SP - 38 VL - 19 IS - 1 AB - Many physiological processes are influenced by nicotinic acetylcholine receptors (nAChR), ranging from neuromuscular and parasympathetic signaling to modulation of the reward system and long-term memory. Due to the complexity of the nAChR family and variable evolutionary rates among its members, their evolution in vertebrates has been difficult to resolve. In order to understand how and when the nAChR genes arose, we have used a broad approach of analyses combining sequence-based phylogeny, chromosomal synteny and intron positions. SN - 1471-2148 UR - https://doi.org/10.1186/s12862-018-1341-8 DO - 10.1186/s12862-018-1341-8 ID - Pedersen2019 ER -