Fig. 5

Amino acid alignment of ApoD genes among species with protein 3D structure annotation. The purple arrow represents the β-strand, and the yellow arrow represents the loop. Sites under positive selection under Bayes empirical Bayes (BEB) with a posterior probability > 95% are labelled with a red rectangle. Most sites under positive selection are distributed on the loops or on the connections between the loop and the β-strand. Note that the positions of the sites under positive selection are based on the codon alignment used for PAML analyses (https://doi.org/10.5061/dryad.39g63v2 [116]) instead of on the amino acid alignment here, but the amino acids that under positive selection are the same in Fig. 5 and https://doi.org/10.5061/dryad.39g63v2 [116]