Fig. 5
From: Origin and development of oligoadenylate synthetase immune system
Phylogenetic analysis of the OAS gene family in vertebrates. a Maximum-likelihood tree of the OAS gene family based on whole length proteins. b Maximum-likelihood tree based on OAS units of OAS family members. OAS2_N and OAS3_N indicate the N terminus of OAS2 and OAS3 proteins. OAS2_C and OAS3_C indicate the C terminus of OAS2 and OAS3 proteins. OAS3_M means the middle domain of the OAS3 protein. c Phylogenetic time tree of OASL genes. We calibrated the molecular clock using a divergence time of 20.90 million years (My) for the mouse-rat common ancestor. Two mammalian OASLs diverged about 173.48 million years ago (Mya) and were orthologous to avian OASL. d Evolutionary model of the OAS family