Fig. 2
Alignment of representative EPDR protein sequences. Comparative alignments of representatives displaying each cysteine residue profile are shown. D. rerio 134034 is a fish ependymin and is included as a representative of profile 1. The signal peptide is indicated by a grey box, and conserved cysteine residues are highlighted in yellow and numbered at the top of the alignment. The sequence logos were calculated from the alignment of all detected EPDR proteins for each profile (see Additional file 4), and thus do not directly correspond to the representative sequences shown. The overall height of each column corresponds to the degree of conservation at that site, and the height of each letter corresponds to the overall frequency of that amino acid. The colouring of species names corresponds to the phylogenetic groups to which the species belong, and follows the scheme established in Fig. 1