Parameter | Description | Range or value |
---|---|---|
α | Tumour emergence rate | 0.5, 0.75, 1. |
λa, i | Cancer initiation rate in the key organ | If scenario 1 or 3, λa, i = 0.01 ∗ i If scenario 2, λa = 0 |
λb, j | Cancer initiation rate in the auxiliary organ | If scenario 2 or 3, λb, j = 0.01 ∗ j If scenario 1, λb = 0 |
i and j | Cancer resistance strategy in the key and the auxiliary organ, respectively. | ℕ ∈ [1, 10] |
b min | The minimal and maximal fecundity rates | 0.1, 0.2, 0.3 |
b max | 0.5 | |
K | Carrying capacity | 10,000 |
d H | Mortality rate of healthy individuals | dH ∼ Unif(10−2, 5.10−2) |
m | Mutation rate | m ∼ Unif(10−10, 10−6) |
τ12, τ23 and τ33 | Probability to have a cancer of stage 2, 3 and 4 (metastasis) when you have a cancer of stage 1, 2 and 3, respectively. | τ12 ∼ Unif(0.1, 0.9) τ23 ∼ Unif(0.1, 0.9) If Scenario 3, τ33 ∼ Unif(0.1,0.9) If Scenario 1 or 2, τ33 = 0 |
δ | The lethality of cancer in the key and the auxiliary organ | δ ∼ Unif(1/10, 1/2)for the key organ and δ ∼ Unif(2, 10) for the auxiliary organ |
c | Constant to manage the strength of cancer impact on organism’s mortality | c ∼ Unif(1, 19) |