Fig. 2
(a) A schematic representation of the population-scale model, (b) the influence of cancer stage on the mortality rate of individuals for different values of lethality δin the key and the auxiliary organs, and (c) the influence of cancer resistance strategies on the fertility rate of individuals for different costs of resistance. In (b), the red and the blue area represent the range of mortality rate for individuals with a key-organ cancer and an auxiliary-organ cancer, respectively. In (c) the black lines represent the fertility rate of individuals with similar resistance strategies in both organs when they are studied in interaction or in only one organ when they are studied in isolation. The grey areas represent the variability of fertility rates when both organs have different resistance strategies. Solid black line and light grey area correspond to a low cost of resistance and dashed black line and dark grey area correspond to an intermediate cost of resistance. For the sake of legibility, the high cost of resistance (bmin = 0.1) is not represented