From: Evolutionary diversity and novelty of DNA repair genes in asexual Bdelloid rotifers
Gene | Gene Description | KO | # | Cel | Dme | Hsa |
---|---|---|---|---|---|---|
Direct Reversal (DR) | ||||||
PHRB | deoxyribodipyrimidine photo lyase | K01669 | 4 | X | ||
ALKBH1 | alkylated DNA repair protein | K10765 | 1 | X | X | X |
MGMT | alkylated DNA repair protein | K00567 | 1 | X | X | X |
Base Excision Repair (BER) | ||||||
FPG | formamidopyrimidine-DNA glycosylase | K10563 | 2 | |||
NEIL1/2/3 | endonuclease VIII like 1,2, or 3 | K10567/8/9 | 0 | X | ||
MPG | DNA-3-methyladenine glycosylase | K03652 | 0 | X | ||
OGG1 | 8-oxoguanine DNA glycosylase | K03660 | 3 | X | X | |
AlkD | DNA alkylation repair enzyme | K00000 | 2 | |||
MUTYH | mutY homolog | K03575 | 2 | X | ||
SMUG1 | ss-selective monofunctional uracil DNA glycosylase | K10800 | 0 | X | ||
MBD4 | methyl-CpG-binding domain protein 4 | K10801 | 0 | X | ||
NTHL1 | nth endonuclease III-like 1 | K10773 | 1 | X | X | X |
TDG/MUG | TDG/ MUG DNA glycosylase family protein | K20813 | 4 | X | X | |
UNG1 | mitochondrial uracil DNA glycosylase | K03648 | 2 | X | X | |
UNG2 | nuclear uracil DNA glycosylase | K03648 | 4 | X | X | |
APEX1 | AP endonuclease 1 | K10771 | 4 | X | X | X |
APEX2 | AP endonuclease 2 | K10772 | 2 | X | ||
PARP1 | poly (ADP-ribose) polymerase family, member 1 | K10798 | 4 | X | X | X |
XRCC1 | X-ray repair complementing defective repair in Chinese hamster cells 1 | K10803 | 2 | X | X | |
TDP1 | tyrosyl-DNA phosphodiesterase 1 | K10862 | 2 | X | X | |
FEN1 | flap endonuclease-1 | K04799 | 3 | X | X | X |
POLB | DNA polymerase beta | K02330 | 2 | X | ||
LIG3 | DNA ligase 3 | K10776 | 2 | X | ||
Nucleotide Excision Repair (NER) | ||||||
RBX1 | RING-box protein 1 | K03868 | 4 | X | X | X |
CUL4 | cullin 4 | K10609 | 4 | X | X | X |
DDB1, XPE | xeroderma pigmentosum group E-complementing protein | K10610 | 3 | X | X | X |
DDB2 | DNA damage binding protein 2 | K10140 | 2 | X | ||
CSA, ERCC8 | excision repair cross-complementing rodent repair deficiency, complementation group 8 | K10570 | 2 | X | X | X |
XPC | xeroderma pigmentosum group C-complementing protein | K10838 | 2 | X | X | X |
RAD23 | UV excision repair protein RAD23 | K10839 | 4 | X | X | X |
CETN2 | centrin-2 | K10840 | 4 | X | ||
XPA | xeroderma pigmentosum group A-complementing protein | K10847 | 2 | X | X | X |
ERCC1 | excision repair cross-complementing rodent repair deficiency, complementation group 1 | K10849 | 2 | X | X | X |
ERCC2, XPD | xeroderma pigmentosum group D-complementing protein | K10844 | 2 | X | X | X |
ERCC3, XPB | xeroderma pigmentosum group B-complementing protein | K10843 | 3 | X | X | X |
ERCC4, XPF | xeroderma pigmentosum group F-complementing protein | K10848 | 2 | X | X | X |
ERCC5, XPG | xeroderma pigmentosum group G-complementing protein | K10846 | 2 | X | X | X |
ERCC6, CSB | excision repair cross-complementing rodent repair deficiency, complementation group 6 | K10841 | 2 | X | X | |
TFIIH1 | transcription initiation factor TFIIH subunit 1 | K03141 | 1 | X | X | X |
TFIIH2 | transcription initiation factor TFIIH subunit 2 | K03142 | 2 | X | X | X |
TFIIH3 | transcription initiation factor TFIIH subunit 3 | K03143 | 1 | X | X | X |
TFIIH4 | transcription initiation factor TFIIH subunit 4 | K03144 | 1 | X | X | X |
MMS19 | DNA repair/transcription protein MET18/MMS19 | K15075 | 1 | X | X | X |
RPB1 | DNA-directed RNA polymerase II subunit RPB1 | K03006 | 4 | X | X | X |
RPB2 | DNA-directed RNA polymerase II subunit RPB2 | K03010 | 2 | X | X | X |
RPB3 | DNA-directed RNA polymerase II subunit RPB3 | K03011 | 1 | X | X | X |
RPB4 | DNA-directed RNA polymerase II subunit RPB4 | K03012 | 2 | X | X | X |
RPB5 | DNA-directed RNA polymerases I, II, and III subunit RPABC1 | K03013 | 4 | X | X | X |
RPB6 | DNA-directed RNA polymerases I, II, and III subunit RPABC2 | K03014 | 4 | X | X | X |
RPB7 | DNA-directed RNA polymerase II subunit RPB7 | K03015 | 2 | X | X | X |
RPB8 | DNA-directed RNA polymerases I, II, and III subunit RPABC3 | K03016 | 2 | X | X | X |
RPB11 | DNA-directed RNA polymerase II subunit RPB11 | K03008 | 2 | X | X | X |
RPB12 | DNA-directed RNA polymerases I, II, and III subunit RPABC4 | K03009 | 2 | X | X | X |
Alternative Excision Repair (AER) | ||||||
UVDE | UV DNA damage endonuclease | K13281 | 2 | |||
SMC6 | structural maintenance of chromosomes 6 | K22804 | 4 | X | X | |
RAD51 | DNA repair protein RAD51 | K04482 | 4 | X | X | X |
RAD54 | DNA repair and recombination protein RAD54 and RAD54-like protein | K10875 | 2 | X | X | X |
RAD54L2 | RAD54-like protein 2 | K10876 | 3 | X | X | X |
EXO1 | exonuclease 1 | K10746 | 2 | X | X | X |
FEN1 | flap endonuclease-1 | K04799 | 3 | X | X | X |
Cross Pathway | ||||||
LIG1 | DNA ligase 1 | K10747 | 2 | X | X | X |
LIGK | DNA ligase (ATP) | K00000 | 4 | |||
PCNA | proliferating cell nuclear antigen | K04802 | 4 | X | X | X |
PNKP | bifunctional polynucleotide phosphatase/kinase | K08073 | 4 | X | X | X |
HMGB1 | high mobility group protein B1 | K10802 | 2 | X | X | |
RFC1 | replication factor C subunit 1 | K10754 | 4 | X | X | X |
RFC2 | replication factor C subunit 2 of RFC2_4 | K10755 | 4 | X | X | X |
RFC4 | replication factor C subunit 4 of RFC2_4 | K10755 | 2 | X | X | X |
RFC3_5 | replication factor C subunit 3_5 | K10756 | 2 | X | X | X |
RPA1 | replication protein A1 | K07466 | 4 | X | X | X |
RPA2 | replication protein A2 | K10739 | 3 | X | X | X |
RPA3 | replication protein A3 | K10740 | 2 | X | X | |
Mismatch Repair (MMR) | ||||||
MSH2 | DNA mismatch repair protein MSH2 | K08735 | 1 | X | X | X |
MSH3 | DNA mismatch repair protein MSH3 | K08736 | 0 | X | ||
MSH6 | DNA mismatch repair protein MSH6 | K08737 | 2 | X | X | X |
MSH4 | DNA mismatch repair protein MSH4, canonically meiotic | K08740 | 2 | X | X | X |
MSH5 | DNA mismatch repair protein MSH5, canonically meiotic | K08741 | 2 | X | X | X |
PMS2 | DNA mismatch repair protein PMS2 | K10858 | 2 | X | X | X |
MLH1 | DNA mismatch repair protein MLH1 | K08734 | 2 | X | X | X |
MLH3 | DNA mismatch repair protein MLH3 | K08739 | 0 | X | ||
EXO1 | exonuclease 1 | K10746 | 2 | X | X | X |
Homologous Recombination (HR) | ||||||
RAD50 | DNA repair protein RAD50 | K10866 | 4 | X | X | X |
MRE11 | double-strand break repair protein MRE11 | K10865 | 2 | X | X | X |
NBS1 | nibrin | K10867 | 0 | X | X | |
ATM | ataxia telangectasia mutated family protein | K04728 | 2 | X | X | X |
RAD51 | DNA repair protein RAD51 | K04482 | 4 | X | X | X |
RAD51L1 | RAD51-like protein 1 | K10869 | 2 | X | ||
RAD51L2 | RAD51-like protein 2 | K10870 | 2 | X | X | |
RAD52 | DNA repair protein RAD52 | K10873 | 0 | X | ||
BRCA2 | breast cancer 2 susceptibility protein | K08775 | 0 | X | ||
RAD54 | DNA repair and recombination protein RAD54 and RAD54-like protein | K10875 | 2 | X | X | X |
RAD54L2 | RAD54-like protein 2 | K10876 | 3 | X | X | X |
EME1 | crossover junction endonuclease EME1 | K10882 | 1 | X | X | |
MUS81 | crossover junction endonuclease MUS81 | K08991 | 2 | X | X | X |
RECQ1 | ATP-dependent DNA helicase Q1 | K10899 | 4 | X | X | |
BLM | Bloom’s syndrome DNA helicase | K10901 | 5 | X | X | X |
RECQL5 | ATP-dependent DNA helicase Q5 | K10902 | 2 | X | X | X |
RMI1 | RecQ-mediated genome instability protein 1 | K10990 | 1 | X | X | |
TOP3A | DNA topoisomerase 3 alpha | K03165 | 2 | X | X | X |
TOP3B | DNA topoisomerase 3 beta | K03165 | 2 | X | X | X |
SLX1 | structure specific endonuclease subunit SLX1 | K15078 | 2 | X | X | X |
SLX4 | structure-specific endonuclease subunit SLX4 | K10484 | 2 | X | ||
GEN1 | Gen homolog 1, endonuclease | K15338 | 2 | X | X | X |
Non-Homologous End Joining (NHEJ) | ||||||
KU70 | ATP-dependent DNA helicase 2 subunit 1 | K10884 | 4 | X | X | X |
KU80 | ATP-dependent DNA helicase 2 subunit 2 | K10885 | 4 | X | X | X |
DNAPKcs | DNA-dependent protein kinase catalytic subunit | K06642 | 3 | X | ||
ARTEMIS | DNA cross-link repair 1C protein | K10887 | 4 | X | ||
APTX | aprataxin | K10863 | 2 | X | X | |
APLF | aprataxin and PNK-like factor | K13295 | 8 | X | X | |
POLL | DNA polymerase lambda | K03512 | 6 | X | ||
XLF | non-homologous end-joining factor 1 | K10980 | 2 | X | ||
XRCC4 | DNA-repair protein XRCC4 | K10886 | 3 | X | ||
LIG4 | DNA ligase 4 | K10777 | 1 | X | ||
Replicative Polymerases (Pol) | ||||||
POLA1 | DNA polymerase alpha subunit A | K02320 | 2 | X | X | X |
POLA2 | DNA polymerase alpha subunit B | K02321 | 2 | X | X | X |
POLD1 | DNA polymerase delta subunit 1 | K02327 | 2 | X | X | X |
POLD2 | DNA polymerase delta subunit 2 | K02328 | 2 | X | X | X |
POLE1 | DNA polymerase epsilon subunit 1 | K02324 | 2 | X | X | X |
POLE2 | DNA polymerase epsilon subunit 2 | K02325 | 2 | X | X | X |
POLG1 | DNA polymerase gamma 1 | K02332 | 2 | X | X | X |
POLG2 | DNA polymerase gamma 2 | K02333 | 2 | X | X | |
Translesion Synthesis (TLS) Polymerases (Pol) | ||||||
POLH | DNA polymerase eta | K03509 | 2 | X | X | X |
POLK | DNA polymerase kappa | K03511 | 2 | X | X | |
POLQ | DNA polymerase theta | K02349 | 1 | X | X | X |
REV1 | DNA polymerase zeta, Rev1 subunit | K03515 | 2 | X | X | X |
REV7 | DNA polymerase zeta, Rev7 subunit | K03508 | 2 | X | ||
REV3L | DNA polymerase zeta, Rev3-like subunit | K02350 | 2 | X | X | X |